ANTIFUNGALS›IMIDAZOLE ANTIFUNGALS
Clotrimazole
lINDICATIONS AND DOSE
Fungal infection in otitis externa
▶TO THE EAR
▶Child:Apply 2 – 3 times a day continue for at least
14 days after disappearance of infectionlSIDE-EFFECTSLocal reaction
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Liquid
▶Canesten (clotrimazole)(Bayer Plc)
Clotrimazole 10 mg per 1 mlCanesten 1 % solution| 20 mlp
£ 2. 30 DT = £ 2. 30
CORTICOSTEROIDS
Betamethasone 21-Dec-2017
lINDICATIONS AND DOSE
BETNESOL®
Eczematous inflammation in otitis externa
▶TO THE EAR
▶Child:Apply 2 – 3 drops every 2 – 3 hours, reduce
frequency when relief obtained
VISTAMETHASONE®
Eczematous inflammation in otitis externa
▶TO THE EAR
▶Child:Apply 2 – 3 drops every 3 – 4 hours, reduce
frequency when relief obtainedIMPORTANT SAFETY INFORMATION
MHRA/CHM ADVICE: CORTICOSTEROIDS: RARE RISK OF CENTRAL
SEROUS CHORIORETINOPATHY WITH LOCAL AS WELL AS SYSTEMIC
ADMINISTRATION (AUGUST 2017)
See Corticosteroids, general use p. 434.lCONTRA-INDICATIONSAvoid alone in the presence of
untreated infection (combine with suitable anti-infective)
lCAUTIONSAvoid prolonged use
lSIDE-EFFECTSLocal reaction
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Ear/eye/nose drops solution
EXCIPIENTS:May contain Benzalkonium chloride, disodium edetate
▶Betnesol(RPH Pharmaceuticals AB)
Betamethasone sodium phosphate 1 mg per 1 mlBetnesol 0. 1 %
eye/ear/nose drops| 10 mlP£ 2. 32 DT = £ 2. 32
▶Vistamethasone(Martindale Pharmaceuticals Ltd)
Betamethasone sodium phosphate 1 mg per 1 mlVistamethasone
0. 1 % ear/eye/nose drops| 5 mlP£ 1. 02 | 10 mlP£ 1. 16 DT =
£ 2. 32
Combinations available:Betamethasone with neomycin,p. 669
Flumetasone pivalate with clioquinol
21-Dec-2017lINDICATIONS AND DOSE
Eczematous inflammation in otitis externa|Mild bacterial
or fungal infections in otitis externa
▶TO THE EAR
▶Child 2–17 years: 2 – 3 drops twice daily for 7 – 10 days, to
be instilled into the earIMPORTANT SAFETY INFORMATION
MHRA/CHM ADVICE: CORTICOSTEROIDS: RARE RISK OF CENTRAL
SEROUS CHORIORETINOPATHY WITH LOCAL AS WELL AS SYSTEMIC
ADMINISTRATION (AUGUST 2017)
See Corticosteroids, general use p. 434.lCONTRA-INDICATIONSIodine sensitivity
lCAUTIONSAvoid prolonged use.manufacturer advises
avoid in perforated tympanic membrane (but used by
specialists for short periods)
lSIDE-EFFECTSParaesthesia.skin reactions
lPATIENT AND CARER ADVICEClioquinol stains skin and
clothinglMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Ear drops
▶Flumetasone pivalate with clioquinol (Non-proprietary)
Flumetasone pivalate 200 microgram per 1 ml, Clioquinol 10 mg
per 1 mlFlumetasone 0. 02 % / Clioquinol 1 % ear drops|
7. 5 mlP£ 11. 34 DT = £ 11. 34 | 10 mlP£ 15. 13 DT = £ 15. 13Prednisolone 21-Dec-2017
lINDICATIONS AND DOSE
Eczematous inflammation in otitis externa
▶TO THE EAR
▶Child:Apply 2 – 3 drops every 2 – 3 hours, frequency to
be reduced when relief obtainedIMPORTANT SAFETY INFORMATION
MHRA/CHM ADVICE: CORTICOSTEROIDS: RARE RISK OF CENTRAL
SEROUS CHORIORETINOPATHY WITH LOCAL AS WELL AS SYSTEMIC
ADMINISTRATION (AUGUST 2017)
See Corticosteroids, general use p. 434.lCONTRA-INDICATIONSAvoid alone in the presence of
untreated infection (combine with suitable anti-infective)
lCAUTIONSAvoid prolonged use
lSIDE-EFFECTSLocal reactionlMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: ear drops
Ear/eye drops solution
EXCIPIENTS:May contain Benzalkonium chloride, disodium edetate
▶Predsol(RPH Pharmaceuticals AB)
Prednisolone sodium phosphate 5 mg per 1 mlPredsol 0. 5 %
ear/eye drops| 10 mlP£ 2. 00 DT = £ 2. 00BNFC 2018 – 2019 Otitis externa 691
Ear, nose and oropharynx12