lSIDE-EFFECTSOedema.pain.paraesthesia.skin reactions
.syncope
lPREGNANCYMinimal absorption from skin; not known to
be harmful.
lPRESCRIBING AND DISPENSING INFORMATIONSpray may
be useful for application of clotrimazole to large or hairy
areas of the skin.
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: powder
Cream
EXCIPIENTS:May contain Benzyl alcohol, cetostearyl alcohol (including
cetyl and stearyl alcohol), polysorbates
▶Clotrimazole (Non-proprietary)
Clotrimazole 10 mg per 1 gramClotrimazole 1 % cream|
20 gramp£ 2. 06 DT = £ 0. 72 | 50 gramp£ 5. 45 DT = £ 1. 80
▶Canesten(Bayer Plc)
Clotrimazole 10 mg per 1 gramCanesten 1 % cream| 20 gramp
£ 2. 20 DT = £ 0. 72 | 50 gramp£ 3. 50 DT = £ 1. 80
Canesten Antifungal 1 % cream| 20 gramp£ 1. 85 DT = £ 0. 72
Canesten Dual Action 1 % cream| 15 gramG£ 2. 14 |
30 gramG£ 2. 76
Clotrimazole 20 mg per 1 gramCanesten 2 % thrush cream|
20 gramp£ 4. 76 DT = £ 4. 76
Clotrimazole 100 mg per 1 gramCanesten Internal 10 % cream|
5 gramp£ 6. 23 DT = £ 6. 23
Canesten 10 % VC cream| 5 gramP£ 4. 50 DT = £ 6. 23
Liquid
▶Canesten(Bayer Plc)
Clotrimazole 10 mg per 1 mlCanesten 1 % solution| 20 mlp
£ 2. 30 DT = £ 2. 30
Spray
CAUTIONARY AND ADVISORY LABELS 15
EXCIPIENTS:May contain propylene glycol
▶Canesten(Bayer Plc)
Clotrimazole 10 mg per 1 mlCanesten Dermatological 1 % spray|
40 mlp£ 4. 72 DT = £ 4. 72
Combinations available:Hydrocortisone with clotrimazole,
p. 743
Econazole nitrate
lINDICATIONS AND DOSE
Fungal skin infections
▶TO THE SKIN
▶Child:Apply twice daily
Fungal nail infections
▶BY TRANSUNGUAL APPLICATION
▶Child:Apply once daily, applied under occlusive
dressinglCAUTIONSAvoid contact with eyes and mucous
membranes
lSIDE-EFFECTS
▶Common or very commonPain.skin reactions
▶UncommonSwelling
▶Frequency not knownAngioedema
SIDE-EFFECTS, FURTHER INFORMATIONTreatment should
be discontinued if side-effects are severe.lPREGNANCYMinimal absorption from skin; not known to
be harmful.
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Cream
EXCIPIENTS:May contain Butylated hydroxyanisole, fragrances
▶Pevaryl(Janssen-Cilag Ltd)
Econazole nitrate 10 mg per 1 gramPevaryl 1 % cream|
30 gramp£ 3. 71
Ketoconazole 20-Jul-2017
lINDICATIONS AND DOSE
Treatment of seborrhoeic dermatitis and dandruff
▶TO THE SKIN USING SHAMPOO
▶Child 12–17 years:Apply twice weekly for 2 – 4 weeks,
leave preparation on for 3 – 5 minutes before rinsing
Prophylaxis of seborrhoeic dermatitis and dandruff
▶TO THE SKIN USING SHAMPOO
▶Child 12–17 years:Apply every 1 – 2 weeks, leave
preparation on for 3 – 5 minutes before rinsing
Treatment of pityriasis versicolor
▶TO THE SKIN USING SHAMPOO
▶Child 12–17 years:Apply once daily for maximum 5 days,
leave preparation on for 3 – 5 minutes before rinsing
Prophylaxis of pityriasis versicolor
▶TO THE SKIN USING SHAMPOO
▶Child 12–17 years:Apply once daily for up to 3 days
before sun exposure, leave preparation on for
3 – 5 minutes before rinsinglCONTRA-INDICATIONSAcute porphyrias p. 603
lCAUTIONSAvoid contact with eyes.avoid contact with
mucous membranes
lINTERACTIONS→Appendix 1 : antifungals, azoles
lSIDE-EFFECTS
▶UncommonExcessive tearing.folliculitis.hair changes.
skin reactions
▶Rare or very rareEye irritation
lEXCEPTIONS TO LEGAL CATEGORYCan be sold to the public
for the prevention and treatment of dandruff and
seborrhoeic dermatitis of the scalp as a shampoo
formulation containing ketoconazole maximum 2 %, in a
pack containing maximum 120 mL and labelled to show a
maximum frequency of application of once every 3 days.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Shampoo
EXCIPIENTS:May contain Imidurea
▶Ketoconazole (Non-proprietary)
Ketoconazole 20 mg per 1 gramKetoconazole 2 % shampoo|
120 mlP£ 3. 60 DT = £ 3. 14
▶Dandrazol(Transdermal Ltd)
Ketoconazole 20 mg per 1 gramDandrazol Anti-dandruff 2 %
shampoo| 60 mlG£ 3. 42 | 100 mlG£ 5. 28
Dandrazol 2 % shampoo| 120 mlP£ 3. 39 DT = £ 3. 14
▶Nizoral(Janssen-Cilag Ltd, McNeil Products Ltd)
Ketoconazole 20 mg per 1 gramNizoral 2 % shampoo|
120 mlP£ 3. 59 DT = £ 3. 14
Nizoral anti-dandruff 2 % shampoo| 60 mlG£ 4. 08
Nizoral Dandruff 2 % shampoo| 100 mlp£ 6. 28Miconazole 11-Oct-2017
lINDICATIONS AND DOSE
Fungal skin infections
▶TO THE SKIN
▶Neonate:Apply twice daily continuing for 10 days after
lesions have healed.▶Child:Apply twice daily continuing for 10 days after
lesions have healed
Fungal nail infections
▶TO THE SKIN
▶Child:Apply 1 – 2 times a daylUNLICENSED USELicensed for use in children (age range
not specified by manufacturer).BNFC 2018 – 2019 Fungal skin infections 725
Skin13