lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension, oral solution
Capsule
CAUTIONARY AND ADVISORY LABELS10, 11, 21
▶Acitretin (Non-proprietary)
Acitretin 10 mgAcitretin 10 mg capsules| 60 capsuleP£ 23. 80
DT = £ 23. 80
Acitretin 25 mgAcitretin 25 mg capsules| 60 capsuleP£ 55. 24
DT = £ 55. 24
▶Neotigason(Teva UK Ltd)
Acitretin 10 mgNeotigason 10 mg capsules| 60 capsuleP
£ 17. 30 DT = £ 23. 80
Acitretin 25 mgNeotigason 25 mg capsules| 60 capsuleP
£ 43. 00 DT = £ 55. 24SALICYLIC ACID AND DERIVATIVES
Salicylic acid with zinc oxide
lINDICATIONS AND DOSE
Hyperkeratotic skin disorders
▶TO THE SKIN
▶Child:Apply twice dailylCAUTIONSAvoid broken skin.avoid inflamed skin
CAUTIONS, FURTHER INFORMATION
▶Salicylate toxicitySalicylate toxicity may occur particularly
if applied on large areas of skin or neonatal skin.
lSIDE-EFFECTSSkin reactions
lPRESCRIBING AND DISPENSING INFORMATIONZinc and
Salicylic Acid Paste BP is also referred to as Lassar’s Paste.
When prepared extemporaneously, the BP states Zinc and
Salicylic Acid Paste, BP (Lassar’s Paste) consists of zinc
oxide 24 %, salicylic acid 2 %, starch 24 %, white soft
paraffin 50 %.lMEDICINAL FORMS
Forms available from special-order manufacturers include:
pasteVITAMINS AND TRACE ELEMENTS›VITAMIN D
AND ANALOGUESCalcipotriol
lINDICATIONS AND DOSE
Plaque psoriasis
▶TO THE SKIN USING OINTMENT
▶Child 6–11 years:Apply twice daily, when preparations
used together maximum total calcipotriol 2. 5 mg in any
one week (e.g. scalp solution 20 mL with ointment
30 g); maximum 50 g per week
▶Child 12–17 years:Apply twice daily, when preparations
used together maximum total calcipotriol 3. 75 mg in
any one week (e.g. scalp solution 30 mL with ointment
45 g); maximum 75 g per week
Scalp psoriasis
▶TO THE SKIN USING SCALP LOTION
▶Child 6–11 years (specialist use only):Apply twice daily,
when preparations used together max. total
calcipotriol 2. 5 mg in any one week (e.g. scalp solution
20 mL with ointment 30 g); maximum 30 mL per week
▶Child 12–17 years (specialist use only):Apply twice daily,
when preparations used together maximum total
calcipotriol 3. 75 mg in any one week (e.g. scalp
solution 30 mL with ointment 45 g); maximum 45 mL
per weeklUNLICENSED USECalcipotriol ointment and scalp solution
not licensed for use in children.lCONTRA-INDICATIONSCalcium metabolism disorders
lCAUTIONSAvoid excessive exposure to sunlight and
sunlamps.avoid use on face.erythrodermic exfoliative
psoriasis (enhanced risk of hypercalcaemia).generalised
pustular psoriasis (enhanced risk of hypercalcaemia)
lINTERACTIONS→Appendix 1 : vitamin D substances
lSIDE-EFFECTS
▶Common or very commonSkin reactions
▶UncommonIncreased risk of infection
▶Rare or very rareHypercalcaemia.hypercalciuria.
photosensitivity reaction
lPREGNANCYManufacturers advise avoid unless essential.
lBREAST FEEDINGNo information available.
lHEPATIC IMPAIRMENTManufacturers advise avoid in
severe impairment.
lRENAL IMPAIRMENTManufacturers advise avoid in severe
impairment.
lPATIENT AND CARER ADVICE
Advice on applicationPatient information leaflet for
Dovonex®ointment advises liberal application. However,
patients should be advised of maximum recommended
weekly dose.
Hands should be washed thoroughly after application to
avoid inadvertent transfer to other body areas.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: ointment
Ointment
EXCIPIENTS:May contain Disodium edetate, propylene glycol
▶Calcipotriol (Non-proprietary)
Calcipotriol 50 microgram per 1 gramCalcipotriol 50 micrograms/g
ointment| 30 gramP£ 5. 78 DT = £ 5. 78 | 60 gramP£ 11. 56 –
£ 13. 86 | 120 gramP£ 23. 12 – £ 27. 72
▶Dovonex(LEO Pharma)
Calcipotriol 50 microgram per 1 gramDovonex 50 micrograms/g
ointment| 30 gramP£ 5. 78 DT = £ 5. 78 | 60 gramP£ 11. 56
Liquid
▶Calcipotriol (Non-proprietary)
Calcipotriol (as Calcipotriol hydrate) 50 microgram per
1mlCalcipotriol 50 micrograms/ml scalp solution| 60 mlP
£ 56. 94 DT = £ 56. 94 | 120 mlP£ 113. 88 DT = £ 113. 88
Combinations available:Calcipotriol with betamethasone,
p. 736Calcitriol
(1,25-Dihydroxycholecalciferol)
lINDICATIONS AND DOSE
Mild to moderate plaque psoriasis
▶TO THE SKIN
▶Child 12–17 years:Apply twice daily, not more than 35 %
of body surface to be treated daily; maximum 30 g per
daylCONTRA-INDICATIONSDo not apply under occlusion.
patients with calcium metabolism disorders
lCAUTIONSErythrodermic exfoliative psoriasis (enhanced
risk of hypercalcaemia).generalised pustular psoriasis
(enhanced risk of hypercalcaemia)
lINTERACTIONS→Appendix 1 : vitamin D substances
lSIDE-EFFECTS
▶Common or very commonSkin reactions
lPREGNANCYManufacturer advises use in restricted
amounts only if clearly necessary.
MonitoringMonitor urine- and serum-calcium
concentration in pregnancy.
lBREAST FEEDINGManufacturer advises avoid.750 Inflammatory skin conditions BNFC 2018 – 2019
Skin13