lPREGNANCYManufacturer advises caution—no
information available.
lBREAST FEEDINGManufacturer advises avoid—no
information available.
lHEPATIC IMPAIRMENT
Dose adjustments 1 – 11 years max. 10 mg daily in severe
impairment. 12 – 17 years max. 20 mg daily in severe
impairment.
lRENAL IMPAIRMENTManufacturer advises caution in
severe renal insufficiency.
lDIRECTIONS FOR ADMINISTRATION
▶With intravenous useForintravenous infusion, dilute
reconstituted solution to a concentration not exceeding
800 micrograms/mL with Sodium Chloride 0. 9 %; give over
10 – 30 minutes.
▶With oral useDo not chew or crush capsules; swallow whole
ormix capsule contents in water and drink within
30 minutes. Do not crush or chew tablets; swallow whole
ordisperse in water and drink within 30 minutes. Disperse
the contents of each sachet of gastro-resistant granules in
approx. 15 mL water. Stir and leave to thicken for a few
minutes; stir again before administration and use within
30 minutes; rinse container with 15 mL water to obtain full
dose. For administration through a gastric tube, consult
product literature.
lPATIENT AND CARER ADVICECounselling on
administration of gastro-resistant capsules, tablets, and
granules advised.
lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral suspension
Gastro-resistant capsule
▶Esomeprazole (Non-proprietary)
Esomeprazole (as Esomeprazole magnesium dihydrate)
20 mgEsomeprazole 20 mg gastro-resistant capsules|
28 capsuleP£ 12. 95 DT = £ 2. 64
Esomeprazole (as Esomeprazole magnesium dihydrate)
40 mgEsomeprazole 40 mg gastro-resistant capsules|
28 capsuleP£ 17. 63 DT = £ 3. 30
▶Emozul(Consilient Health Ltd)
Esomeprazole (as Esomeprazole magnesium dihydrate)
20 mgEmozul 20 mg gastro-resistant capsules| 28 capsuleP
£ 2. 64 DT = £ 2. 64
Esomeprazole (as Esomeprazole magnesium dihydrate)
40 mgEmozul 40 mg gastro-resistant capsules| 28 capsuleP
£ 3. 30 DT = £ 3. 30
▶Ventra(Ethypharm UK Ltd)
Esomeprazole (as Esomeprazole magnesium dihydrate)
20 mgVentra 20 mg gastro-resistant capsules| 28 capsuleP
£ 2. 55 DT = £ 2. 64
Esomeprazole (as Esomeprazole magnesium dihydrate)
40 mgVentra 40 mg gastro-resistant capsules| 28 capsuleP
£ 2. 97 DT = £ 3. 30
Gastro-resistant tablet
▶Esomeprazole (Non-proprietary)
Esomeprazole (as Esomeprazole magnesium trihydrate)
20 mgEsomeprazole 20 mg gastro-resistant tablets| 28 tabletP
£ 18. 50 DT = £ 2. 32
Esomeprazole (as Esomeprazole magnesium trihydrate)
40 mgEsomeprazole 40 mg gastro-resistant tablets| 28 tabletP
£ 25. 19 DT = £ 2. 91
▶Nexium(AstraZeneca UK Ltd, Pfizer Consumer Healthcare Ltd)
Esomeprazole (as Esomeprazole magnesium trihydrate)
20 mgNexium 20 mg gastro-resistant tablets| 28 tabletP
£ 18. 50 DT = £ 2. 32
Esomeprazole (as Esomeprazole magnesium trihydrate)
40 mgNexium 40 mg gastro-resistant tablets| 28 tabletP
£ 25. 19 DT = £ 2. 91
Powder for solution for injection
▶Esomeprazole (Non-proprietary)
Esomeprazole (as Esomeprazole sodium) 40 mgEsomeprazole
40 mg powder for solution for injection vials| 1 vialP£ 3. 13
(Hospital only)| 1 vialP£ 3. 07
▶Nexium(AstraZeneca UK Ltd)
Esomeprazole (as Esomeprazole sodium) 40 mgNexium I.V 40 mg
powder for solution for injection vials| 1 vialP£ 4. 25 (Hospital
only)
Gastro-resistant granules
CAUTIONARY AND ADVISORY LABELS 25
▶Nexium(AstraZeneca UK Ltd)
Esomeprazole (as Esomeprazole magnesium trihydrate)
10 mgNexium 10 mg gastro-resistant granules sachets|
28 sachetP£ 25. 19 DT = £ 25. 19
eiiiiF 56Lansoprazole 07-Jun-2017
lINDICATIONS AND DOSE
Benign gastric ulcer
▶BY MOUTH
▶Child (body-weight up to 30 kg): 0. 5 – 1 mg/kg once daily
(max. per dose 15 mg once daily), doses to be taken in
the morning
▶Child (body-weight 30 kg and above): 15 – 30 mg once
daily, doses to be taken in the morning
Duodenal ulcer
▶BY MOUTH
▶Child (body-weight up to 30 kg): 0. 5 – 1 mg/kg once daily
(max. per dose 15 mg once daily), doses to be taken in
the morning
▶Child (body-weight 30 kg and above): 15 – 30 mg once
daily, doses to be taken in the morning
NSAID-associated duodenal ulcer|NSAID-associated
gastric ulcer
▶BY MOUTH
▶Child (body-weight up to 30 kg): 0. 5 – 1 mg/kg once daily
(max. per dose 15 mg once daily), doses to be taken in
the morning
▶Child (body-weight 30 kg and above): 15 – 30 mg once
daily, doses to be taken in the morning
Gastro-oesophageal reflux disease
▶BY MOUTH
▶Child (body-weight up to 30 kg): 0. 5 – 1 mg/kg once daily
(max. per dose 15 mg once daily), doses to be taken in
the morning
▶Child (body-weight 30 kg and above): 15 – 30 mg once
daily, doses to be taken in the morning
Acid-related dyspepsia
▶BY MOUTH
▶Child (body-weight up to 30 kg): 0. 5 – 1 mg/kg once daily
(max. per dose 15 mg once daily), doses to be taken in
the morning
▶Child (body-weight 30 kg and above): 15 – 30 mg once
daily, doses to be taken in the morning
Fat malabsorption despite pancreatic enzyme
replacement therapy in cystic fibrosis
▶BY MOUTH
▶Child (body-weight up to 30 kg): 0. 5 – 1 mg/kg once daily
(max. per dose 15 mg once daily), doses to be taken in
the morning
▶Child (body-weight 30 kg and above): 15 – 30 mg once
daily, doses to be taken in the morninglUNLICENSED USENot licensed for use in children.
lINTERACTIONS→Appendix 1 : proton pump inhibitors
lSIDE-EFFECTS
▶Common or very commonDry throat.fatigue
▶UncommonEosinophilia.oedema
▶Rare or very rareAnaemia.angioedema.appetite
decreased.colitis.erectile dysfunction.fever.glossitis.
oesophageal candidiasis.pancreatitis.restlessness.
tremor
lPREGNANCYManufacturer advises avoid.
lBREAST FEEDINGAvoid—present in milk inanimalstudies.BNFC 2018 – 2019 Gastric and duodenal ulceration 57
Gastro-intestinal system1