TABLE 1
Drugs that cause hepatotoxicity
The following is a list of some drugs that cause hepatotoxicity (note that this list is not exhaustive). Concurrent use of two or more drugs
from the list might increase this risk.
alcohol (beverage)
alectinib
asparaginase
atorvastatin
carbamazepine
clavulanic acid
crisantaspase
dactinomycin
dantrolene
demeclocycline
didanosine
doxycycline
flucloxacillin
fluconazole
fluvastatin
isoniaziditraconazole
leflunomide
lenalidomide
lomitapide
lymecycline
mercaptopurine
methotrexate
micafunginminocycline
oxytetracycline
paracetamol
pegaspargase
pravastatin
rosuvastatin
simvastatin
sulfasalazinetetracycline
tigecycline
trabectedin
valproate
vincristineTABLE 2
Drugs that cause nephrotoxicity
The following is a list of some drugs that cause nephrotoxicity (note that this list is not exhaustive). Concurrent use of two or more drugs
from the list might increase this risk.
aceclofenac
acemetacin
aciclovir
amikacin
amphotericin
bacitracin
capreomycin
carboplatin
cefaclor
cefadroxil
cefalexin
cefixime
cefotaxime
cefradine
ceftaroline
ceftazidime
ceftobiprole
ceftolozane
ceftriaxone
cefuroxime
celecoxib
ciclosporin
cisplatin
colistimethate (particularly
intravenous)
dexibuprofen
dexketoprofen
diclofenacetodolac
etoricoxib
fenoprofen
flurbiprofen
foscarnet
ganciclovir
gentamicin
ibuprofen
ifosfamide
indometacin
ketoprofen
ketorolac
mefenamic acid
meloxicammethotrexate
nabumetone
naproxen
neomycin
oxaliplatin
parecoxib
pemetrexed
penicillamine
pentamidine
piroxicam
polymyxins
streptomycin
sulindac
tacrolimustelavancin
tenofovir disoproxil
tenoxicam
tiaprofenic acid
tobramycin
tolfenamic acid
trimethoprim
valaciclovir
valganciclovir
vancomycin
zidovudine
zoledronic acidTABLE 3
Drugs with anticoagulant effects
The following is a list of drugs that have anticoagulant effects. Concurrent use of two or more drugs from this list might increase the risk
of bleeding; concurrent use of drugs with antiplatelet effects (see table of drugs with antiplatelet effects) might also increase this risk.
acenocoumarol
alteplase
apixaban
argatroban
bivalirudin
dabigatran
dalteparin
danaparoid
edoxaban
enoxaparinfondaparinux
glucose
heparin (unfractionated)
nicotinic acid
omega-3-acid ethyl estersphenindione
rivaroxaban
streptokinase
tenecteplase
tinzaparinurokinase
warfarinTABLE 4
Drugs with antiplatelet effects
The following is a list of drugs that have antiplatelet effects (note that this list is not exhaustive). Concurrent use of two or more drugs
from this list might increase the risk of bleeding; concurrent use of drugs with anticoagulant effects (see table of drugs with anticoagulant
effects) might also increase this risk.
abciximab
aceclofenac
acemetacin
anagrelide
aspirin
bevacizumab
cangrelor
celecoxib
cilostazol
citalopram
clopidogrel
dapoxetine
dasatinib
dexibuprofen
dexketoprofen
diclofenac
dipyridamole
duloxetine
epoprostenol
eptifibatide
escitalopram
etodolacetoricoxib
fenoprofen
fluoxetine
flurbiprofen
fluvoxamine
ibrutinib
ibuprofen
iloprost
indometacin
ketoprofen
ketorolacmefenamic acid
meloxicam
nabumetone
naproxen
parecoxib
paroxetine
piroxicam
prasugrel
regorafenib
sertraline
sulfinpyrazonesulindac
tenoxicam
tiaprofenic acid
ticagrelor
tirofiban
tolfenamic acid
trastuzumab
trastuzumab emtansine
venlafaxine
vortioxetineTABLE 5
Drugs that cause thromboembolism
The following is a list of some drugs that cause thromboembolism (note that this list is not exhaustive). Concurrent use of two or more
drugs from the list might increase this risk.
bleomycin
cyclophosphamide
darbepoetin alfa
doxorubicin
epoetin alfa
epoetin beta
epoetin zeta
fluorouracil
fulvestrant
lenalidomide
methotrexate
mitomycinpentostatin
pomalidomide
raloxifene
tamoxifen
thalidomide
tibolonetoremifene
tranexamic acid
tretinoin
vinblastine
vincristine
vindesinevinflunine
vinorelbineBNFC 2018 – 2019 Appendix 1 Interactions 847
Interactions|Appendix 1A1