Agalsidase
▶Aminoglycosidesare predicted to decrease the effects of
agalsidase. Avoid.oTheoretical
▶Antiarrhythmics(amiodarone)are predicted to decrease the
effects ofagalsidase. Avoid.oTheoretical
▶Antimalarials(chloroquine)are predicted to decrease the effects
ofagalsidase. Avoid.oTheoretical
▶Hydroxychloroquineis predicted to decrease the effects of
agalsidase.oTheoretical
Agomelatine→seeTABLE 11p. 849 (CNS depressant effects)
▶Dose adjustment might be necessary if smoking started or
stopped during treatment.
▶Caution with concomitant use of drugs associated with
hepatic injury.▶Antiepileptics(fosphenytoin, phenytoin)are predicted to
decrease the exposure toagomelatine.oTheoretical
▶Combined hormonal contraceptivesare predicted to increase
the exposure toagomelatine.oStudy
▶HIV-protease inhibitors(ritonavir)are predicted to decrease the
exposure toagomelatine.oTheoretical
▶Leflunomideis predicted to decrease the exposure to
agomelatine.oTheoretical
▶Quinolones(ciprofloxacin)are predicted to increase the
exposure toagomelatine.oStudy
▶Rifampicinis predicted to decrease the exposure to
agomelatine.oTheoretical
▶SSRIs(fluvoxamine)very markedly increase the exposure to
agomelatine. Avoid.rStudy
▶Teriflunomideis predicted to decrease the exposure to
agomelatine.oTheoretical
Albendazole
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)decrease the concentration of
albendazole.oStudy
▶H 2 receptor antagonists(cimetidine)decrease the clearance of
albendazole.oStudy
▶HIV-protease inhibitors(ritonavir)decrease the exposure to
albendazole.oStudy
▶Albendazoleslightly decreases the exposure tolevamisoleand
levamisolemoderately decreases the exposure toalbendazole.
oStudy
Albiglutide→seeTABLE 14p. 850 (antidiabetic drugs)
Alcohol (beverage)→seeTABLE 1p. 847 (hepatotoxicity),TABLE 8
p. 848 (hypotension),TABLE 11p. 849 (CNS depressant effects)
▶Alcohol (beverage)potentially increases the risk of visual
disturbances when given withantiepileptics(retigabine).
oStudy
▶Alcohol (beverage)potentially causes a disulfiram-like
reaction when given withantifungals, azoles(ketoconazole).
Avoid.oAnecdotal
▶Alcohol (beverage)causes serious, potentially fatal, CNS
depression when given withclomethiazole. Avoid.r
Study→Also seeTABLE 11p. 849
▶Alcohol (beverage)(in those who drink heavily) potentially
decreases the anticoagulant effect ofcoumarins.rStudy
▶Alcohol (beverage)(excessive consumption) potentially
increases the risk of gastrointestinal side-effects when given
withdimethyl fumarate. Avoid.oTheoretical
▶Alcohol (beverage)causes an extremely unpleasant systemic
reaction when given withdisulfiram. Avoid for at least
24 hours before and up to 14 days after stopping treatment.
rStudy
▶Alcohol (beverage)potentially causes a disulfiram-like
reaction when given withgriseofulvin.oAnecdotal
▶Alcohol (beverage)potentially causes a disulfiram-like
reaction when given withlevamisole.oStudy
▶Alcohol (beverage)(excessive consumption) potentially
increases the risk of lactic acidosis when given with
metformin. Avoid excessive alcohol consumption.o
Theoretical
▶Alcohol (beverage)potentially causes a disulfiram-like
reaction when given withmetronidazole. Avoid for at least
48 hours stopping treatment.oStudy
▶Alcohol (beverage)causes rapid release ofopioids
(hydromorphone, morphine)(from extended-release
preparations). Avoid.rStudy→Also seeTABLE 11p. 849
▶Alcohol (beverage)(in those who drink heavily) causes severe
liver damage when given withparacetamol.rStudy→Also
seeTABLE 1p. 847
▶Alcohol (beverage)increases the risk of facialflushing and skin
irritation when given with topicalpimecrolimus.o
Study
▶Alcohol (beverage)potentially causes a disulfiram-like
reaction when given withprocarbazine.oAnecdotal
▶Alcohol (beverage)potentially increases the concentration of
retinoids(acitretin). Avoid and for 2 months after stopping
acitretin.oStudy
▶Alcohol (beverage)increases the risk of facialflushing and skin
irritation when given with topicaltacrolimus.oStudy
▶Alcohol (beverage)potentially causes a disulfiram-like
reaction when given withtinidazole. Avoid for 72 hours
stopping treatment.oTheoretical
Aldosterone antagonists→seeTABLE 18p. 851 (hyponatraemia),
TABLE 8p. 848 (hypotension),TABLE 16p. 851 (increased serum
potassium)eplerenone.spironolactone..
▶Antiarrhythmics(amiodarone)are predicted to increase the
exposure toeplerenone. Adjusteplerenonedose.r
Theoretical
▶Antiarrhythmics(dronedarone)are predicted to increase the
exposure toeplerenone. Adjusteplerenonedose.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toeplerenone. Avoid.oTheoretical→Also seeTABLE 18
p. 851
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure toeplerenone. Adjust
eplerenonedose.rStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to markedly increase the exposure toeplerenone.
Avoid.rStudy
▶Aprepitantis predicted to increase the exposure toeplerenone.
Adjusteplerenonedose.rStudy
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure toeplerenone. Adjusteplerenonedose.
rStudy→Also seeTABLE 8p. 848
▶Cobicistatis predicted to markedly increase the exposure to
eplerenone. Avoid.rStudy
▶Crizotinibis predicted to increase the exposure toeplerenone.
Adjusteplerenonedose.rStudy
▶Eplerenonevery slightly increases the exposure todigoxin.
nStudy
▶Spironolactoneincreases the concentration ofdigoxin.
Monitor and adjust dose.oStudy
▶Enzalutamideis predicted to decrease the exposure to
eplerenone. Avoid.oTheoretical
▶HIV-protease inhibitorsare predicted to markedly increase the
exposure toeplerenone. Avoid.rStudy
▶Idelalisibis predicted to markedly increase the exposure to
eplerenone. Avoid.rStudy
▶Imatinibis predicted to increase the exposure toeplerenone.
Adjusteplerenonedose.rStudy
▶Eplerenonepotentially increases the concentration oflithium.
Avoid.oTheoretical
▶Spironolactonepotentially increases the concentration of
lithium.oStudy
▶Macrolides(clarithromycin)are predicted to markedly increase
the exposure toeplerenone. Avoid.rStudy
▶Macrolides(erythromycin)are predicted to increase the
exposure toeplerenone. Adjusteplerenonedose.rStudy
▶Mitotaneis predicted to decrease the exposure toeplerenone.
Avoid.oTheoretical
▶Spironolactoneis predicted to decrease the effects ofmitotane.
Avoid.rAnecdotal
▶Netupitantis predicted to increase the exposure toeplerenone.
Adjusteplerenonedose.rStudy
▶Nilotinibis predicted to increase the exposure toeplerenone.
Adjusteplerenonedose.rStudyBNFC 2018 – 2019 Agalsidase—Aldosterone antagonists 853
Interactions|Appendix 1A1