torisperidone. Adjust dose.oStudy→Also seeTABLE 11
p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to moderately decrease
the exposure torivaroxaban. Avoid unless patient can be
monitored for signs of thrombosis.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toroflumilast. Avoid.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to markedly decrease the
exposure torolapitant. Avoid.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toruxolitinib. Monitor and adjust dose.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to moderately decrease
the exposure tosaxagliptin.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenytoin)are
predicted to decrease the exposure to the active metabolite of
selexipag. Adjust dose.oStudy
▶Valproateis predicted to increase the exposure toselexipag.
qTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tosimeprevir. Avoid.rStudy
▶Oxcarbazepineis predicted to decrease the exposure to
simeprevir. Avoid.rTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the
concentration ofsirolimus. Avoid.rStudy
▶Valproateincreases the exposure tosodium oxybate. Adjust
sodium oxybatedose.oStudy
▶Valproatepotentially decreases the effects ofsodium
phenylbutyrate.oAnecdotal
▶Antiepileptics(fosphenytoin, oxcarbazepine, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tosofosbuvir. Avoid.rTheoretical
▶Carbamazepineis predicted to decrease the exposure to
sofosbuvir. Avoid.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tosolifenacin.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tosorafenib.oTheoretical
▶SSRIs(fluoxetine, fluvoxamine)are predicted to increase the
concentration ofantiepileptics(fosphenytoin, phenytoin).
Monitor and adjust dose.rAnecdotal
▶SSRIs(sertraline)potentially increase the risk of toxicity when
given withantiepileptics(fosphenytoin, phenytoin). Monitor
concentration and adjust dose.rAnecdotal
▶Antiepileptics(fosphenytoin, phenytoin)decrease the
concentration ofSSRIs(paroxetine).oStudy
▶St John’s Wortis predicted to decrease the concentration of
antiepileptics(fosphenytoin, phenobarbital, phenytoin,
primidone). Avoid.rTheoretical
▶St John’s Wortis predicted to decrease the exposure to
brivaracetam.oTheoretical
▶St John’s Wortis predicted to decrease the concentration of
carbamazepine. Monitor and adjust dose.oTheoretical
▶St John’s Wortis predicted to decrease the exposure to
perampanel. Monitor and adjust dose.oTheoretical
▶St John’s Wortis predicted to decrease the exposure to
tiagabine. Avoid.nTheoretical
▶Antiepileptics(carbamazepine, eslicarbazepine)are predicted to
decrease the exposure tostatins(atorvastatin). Monitor and
adjust dose.oTheoretical→Also seeTABLE 1p. 847
▶Antiepileptics(fosphenytoin, phenytoin)potentially decrease
the exposure tostatins(atorvastatin, simvastatin).o
Anecdotal
▶Carbamazepinemoderately decreases the exposure tostatins
(simvastatin). Monitor and adjust dose.rStudy→Also see
TABLE 1p. 847
▶Eslicarbazepinemoderately decreases the exposure tostatins
(simvastatin). Monitor and adjust dose.oStudy
▶Sulfinpyrazoneincreases the concentration ofantiepileptics
(fosphenytoin, phenytoin).oStudy
▶Sulfonamides(sulfadiazine)are predicted to increase the
concentration offosphenytoin. Monitor and adjust dose.
oStudy
▶Sulfonamides(sulfadiazine)increase the concentration of
phenytoin. Monitor and adjust dose.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tosunitinib. Avoid or adjustsunitinibdose.oStudy
▶Antiepileptics(fosphenytoin, phenytoin)increase the effects of
suxamethonium.oStudy
▶Carbamazepineincreases the risk of prolonged neuromuscular
blockade when given withsuxamethonium.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)decrease the concentration of
tacrolimus. Monitor and adjust dose.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
totaxanes(cabazitaxel, paclitaxel). Avoid.rStudy→Also
seeTABLE 12p. 850
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
totaxanes(docetaxel).rTheoretical→Also seeTABLE 12
p. 850
▶Tegafurpotentially increases the concentration of
antiepileptics(fosphenytoin, phenytoin). Monitor concentration
and adjust dose.rAnecdotal
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the
concentration oftemsirolimus. Avoid.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, oxcarbazepine,
phenobarbital, phenytoin, primidone)are predicted to decrease
the exposure totenofovir alafenamide. Avoid.o
Theoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)decrease the exposure totetracyclines
(doxycycline). Monitor and adjust dose.oStudy→Also
seeTABLE 1p. 847
▶Antiepileptics(fosphenytoin, phenytoin)are predicted to
decrease the exposure totheophylline. Adjust dose.o
Study
▶Antiepileptics(phenobarbital, primidone)are predicted to
increase the clearance oftheophylline. Adjust dose.o
Theoretical
▶Carbamazepinepotentially increases the clearance of
theophyllineandtheophyllinedecreases the exposure to
carbamazepine. Adjust dose.oAnecdotal
▶Stiripentolis predicted to increase the exposure to
theophylline. Avoid.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenytoin)are
predicted to increase the risk of hypothyroidism when given
withthyroid hormones.oStudy
▶Antiepileptics(phenobarbital, primidone)are predicted to
decrease the effects ofthyroid hormones.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to markedly decrease the
exposure toticagrelor. Avoid.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
totivozanib.rStudy
▶Antiepileptics(fosphenytoin, phenytoin)moderately decrease
the exposure totizanidine.nStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
totofacitinib. Avoid.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
totolvaptan. Avoid.rStudy
▶Antiepileptics(fosphenytoin, phenytoin)increase the clearance
oftopotecan.oStudyBNFC 2018 – 2019 Antiepileptics—Antiepileptics 869
Interactions|Appendix 1A1