▶Antifungals, azoles(fluconazole, miconazole)are predicted to
increase the exposure tosulfonylureas. Use with caution and
adjust dose.oStudy
▶Voriconazoleis predicted to increase the concentration of
sulfonylureas. Use with caution and adjust dose.o
Study
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure tosunitinib.o
Theoretical→Also seeTABLE 9p. 849
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to slightly increase the exposure tosunitinib. Avoid
or adjustsunitinibdose.oStudy→Also seeTABLE 9p. 849
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the concentration oftacrolimus.
rStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the concentration oftacrolimus. Monitor
and adjust dose.rStudy
▶Miconazoleis predicted to increase the concentration of
tacrolimus. Monitor and adjust dose.rTheoretical
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure totaxanes(cabazitaxel).
oTheoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure totaxanes(cabazitaxel).
Avoid.rStudy
▶Miconazoleis predicted to increase the concentration of
taxanes(docetaxel). Use with caution and adjust dose.
oTheoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to moderately increase the exposure totaxanes
(docetaxel). Avoid or adjust dose.rStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure totaxanes(paclitaxel).
rTheoretical
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the concentration oftemsirolimus.
oTheoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the concentration oftemsirolimus.
Avoid.rTheoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to markedly increase the exposure toticagrelor.
Avoid.rStudy
▶Antifungals, azoles(fluconazole, itraconazole, ketoconazole,
voriconazole)are predicted to increase the exposure to
tofacitinib. Adjusttofacitinibdose.oStudy
▶Isavuconazoleis predicted to increase the exposure to
tofacitinib.oStudy
▶Posaconazoleis predicted to increase the exposure to
tofacitinib.oTheoretical
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure totolterodine.n
Theoretical→Also seeTABLE 9p. 849
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure totolterodine. Avoid.
rStudy→Also seeTABLE 9p. 849
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure totolvaptan. Adjust
dose.oStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure totolvaptan. Adjust dose.
rStudy
▶Antifungals, azoles(itraconazole, ketoconazole)are predicted to
increase the exposure totopotecan.rStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure totoremifene.o
Theoretical→Also seeTABLE 9p. 849
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure totrabectedin. Avoid or
adjust dose.rTheoretical→Also seeTABLE 1p. 847
▶Antifungals, azoles(itraconazole, ketoconazole)are predicted to
increase the concentration oftrametinib.oTheoretical
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure totrazodone.o
Theoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to moderately increase the exposure totrazodone.
Avoid or adjust dose.oStudy
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure toulipristal. Avoid if
used for uterinefibroids.oStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure toulipristal. Avoid if used
for uterinefibroids.rStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure tovemurafenib.r
Theoretical→Also seeTABLE 9p. 849
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure tovenetoclax. Avoid
moderate inhibitors of CYP3A4 or adjustvenetoclaxdose.
rStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure tovenetoclax. Avoid potent
inhibitors of CYP3A4 or adjustvenetoclaxdose.rStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure tovenlafaxine.o
Study→Also seeTABLE 9p. 849
▶Antifungals, azoles(fluconazole, isavuconazole, itraconazole,
ketoconazole, posaconazole, voriconazole)are predicted to
increase the exposure tovinca alkaloids.rTheoretical→
Also seeTABLE 1p. 847→Also seeTABLE 9p. 849
▶Miconazoleis predicted to increase the concentration ofvinca
alkaloids. Use with caution and adjust dose.o
Theoretical
▶Antifungals, azoles(clotrimazole, ketoconazole)are predicted to
decrease the exposure tovitamin D substances(colecalciferol).
oTheoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure tovitamin D substances
(paricalcitol).oStudy
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure tozopiclone. Adjust
dose.oStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure tozopiclone. Adjust dose.
oTheoretical
Antihistamines, non-sedating→seeTABLE 9p. 849 (QT-interval
prolongation)
acrivastine.azelastine.bilastine.cetirizine.desloratadine.
fexofenadine.levocetirizine.loratadine.mizolastine.rupatadine..FOOD AND LIFESTYLEApple juice and orange juice decrease the
exposure to fexofenadine.
▶Antacidsdecrease the absorption offexofenadine. Separate
administration by 2 hours.nStudy
▶Antiarrhythmics(dronedarone)are predicted to increase the
exposure torupatadine. Avoid.oStudy
▶Antiarrhythmics(dronedarone)are predicted to increase the
exposure toantihistamines, non-sedating(fexofenadine,
mizolastine).rTheoretical
▶Antifungals, azoles(fluconazole, isavuconazole, itraconazole,
ketoconazole, posaconazole, voriconazole)are predicted to
increase the exposure torupatadine. Avoid.oStudy
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure tomizolastine.r
Theoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure tomizolastine. Avoid.
rStudy
▶Antifungals, azoles(miconazole)are predicted to increase the
exposure tomizolastine. Avoid.oTheoretical
▶Aprepitantis predicted to increase the exposure tomizolastine.
rTheoretical
▶Aprepitantis predicted to increase the exposure torupatadine.
Avoid.oStudy
▶Antihistamines, non-sedatingare predicted to decrease the
effects ofbetahistine.oTheoreticalBNFC 2018 – 2019 Antifungals, azoles—Antihistamines, non-sedating 877
Interactions|Appendix 1A1