Darifenacin(continued)
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to slightly increase the exposure todarifenacin.
oStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to markedly to very markedly increase the exposure
todarifenacin. Avoid.rStudy
▶Aprepitantis predicted to slightly increase the exposure to
darifenacin.oStudy
▶Bupropionis predicted to slightly increase the exposure to
darifenacin.nStudy
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
slightly increase the exposure todarifenacin.oStudy
▶Ciclosporinis predicted to increase the exposure to
darifenacin. Avoid.oTheoretical
▶Cinacalcetis predicted to slightly increase the exposure to
darifenacin.nStudy
▶Cobicistatis predicted to markedly to very markedly increase
the exposure todarifenacin. Avoid.rStudy
▶Crizotinibis predicted to slightly increase the exposure to
darifenacin.oStudy
▶Enzalutamideis predicted to decrease the exposure to
darifenacin.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
darifenacin.oStudy
▶HIV-protease inhibitorsare predicted to markedly to very
markedly increase the exposure todarifenacin. Avoid.r
Study
▶Idelalisibis predicted to markedly to very markedly increase
the exposure todarifenacin. Avoid.rStudy
▶Imatinibis predicted to slightly increase the exposure to
darifenacin.oStudy
▶Macrolides(clarithromycin)are predicted to markedly to very
markedly increase the exposure todarifenacin. Avoid.r
Study
▶Macrolides(erythromycin)are predicted to slightly increase the
exposure todarifenacin.oStudy
▶Mitotaneis predicted to decrease the exposure todarifenacin.
oTheoretical
▶Netupitantis predicted to slightly increase the exposure to
darifenacin.oStudy
▶Nilotinibis predicted to slightly increase the exposure to
darifenacin.oStudy
▶Rifampicinis predicted to decrease the exposure to
darifenacin.oTheoretical
▶SSRIs(fluoxetine, paroxetine)are predicted to slightly increase
the exposure todarifenacin.nStudy
▶St John’s Wortis predicted to decrease the exposure to
darifenacin.oTheoretical
▶Terbinafineis predicted to slightly increase the exposure to
darifenacin.nStudy
▶Darifenacinis predicted to increase the exposure totricyclic
antidepressants.oTheoretical→Also seeTABLE 10p. 849
Darunavir→see HIV-protease inhibitors
Dasabuvir
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
todasabuvir. Avoid.rTheoretical
▶Combined hormonal contraceptivesincrease the risk of raised
liver function tests when given withdasabuvir. Avoid.r
Study
▶Enzalutamideis predicted to decrease the exposure to
dasabuvir. Avoid.rTheoretical
▶Fibrates(gemfibrozil)very markedly increase the exposure to
dasabuvir. Avoid.rStudy
▶Dasabuvir(with ombitasvir, paritaprevir and ritonavir)
increases the concentration ofloop diuretics(furosemide).
Adjust dose.oStudy
▶Rifampicinis predicted to decrease the exposure todasabuvir.
Avoid.rTheoretical
▶St John’s Wortis predicted to decrease the exposure to
dasabuvir. Avoid.rTheoretical
▶Dasabuvirincreases the exposure tostatins(rosuvastatin).
Adjustrosuvastatindose,p. 133.oStudyDasatinib→seeTABLE 15p. 850 (myelosuppression),TABLE 9p. 849
(QT-interval prolongation),TABLE 4p. 847 (antiplatelet effects)
▶Antacidsdecrease the absorption ofdasatinib. Separate
administration by at least 2 hours.oStudy
▶Antiarrhythmics(dronedarone)are predicted to increase the
exposure todasatinib.rStudy→Also seeTABLE 9p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to markedly decrease the
exposure todasatinib. Avoid.rStudy
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure todasatinib.r
Study→Also seeTABLE 9p. 849
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to markedly increase the exposure todasatinib.
Avoid.rStudy→Also seeTABLE 9p. 849
▶Aprepitantis predicted to increase the exposure todasatinib.
rStudy
▶Bosentanis predicted to decrease the exposure todasatinib.
rStudy
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure todasatinib.rStudy
▶Cobicistatis predicted to markedly increase the exposure to
dasatinib. Avoid.rStudy
▶Dasatinibis predicted to increase the risk of bleeding events
when given withcoumarins.rTheoretical
▶Crizotinibis predicted to increase the exposure todasatinib.
rStudy→Also seeTABLE 15p. 850→Also seeTABLE 9p. 849
▶Efavirenzis predicted to decrease the exposure todasatinib.
rStudy→Also seeTABLE 9p. 849
▶Enzalutamideis predicted to markedly decrease the exposure
todasatinib. Avoid.rStudy
▶Grapefruit juiceis predicted to increase the exposure to
dasatinib. Avoid.oTheoretical
▶H 2 receptor antagonistsare predicted to decrease the exposure
todasatinib. Avoid.oStudy
▶HIV-protease inhibitorsare predicted to markedly increase the
exposure todasatinib. Avoid.rStudy→Also seeTABLE 9
p. 849
▶Idelalisibis predicted to markedly increase the exposure to
dasatinib. Avoid.rStudy→Also seeTABLE 15p. 850
▶Imatinibis predicted to increase the exposure todasatinib.
rStudy→Also seeTABLE 15p. 850
▶Macrolides(clarithromycin)are predicted to markedly increase
the exposure todasatinib. Avoid.rStudy→Also see
TABLE 9p. 849
▶Macrolides(erythromycin)are predicted to increase the
exposure todasatinib.rStudy→Also seeTABLE 9p. 849
▶Mitotaneis predicted to markedly decrease the exposure to
dasatinib. Avoid.rStudy→Also seeTABLE 15p. 850
▶Netupitantis predicted to increase the exposure todasatinib.
rStudy
▶Nevirapineis predicted to decrease the exposure todasatinib.
rStudy
▶Nilotinibis predicted to increase the exposure todasatinib.
rStudy→Also seeTABLE 15p. 850→Also seeTABLE 9p. 849
▶Dasatinibis predicted to increase the risk of bleeding events
when given withphenindione.rTheoretical
▶Pitolisantis predicted to decrease the exposure todasatinib.
Avoid.rTheoretical
▶Proton pump inhibitorsare predicted to slightly to moderately
decrease the exposure todasatinib. Avoid.rStudy
▶Rifampicinis predicted to markedly decrease the exposure to
dasatinib. Avoid.rStudy
▶St John’s Wortis predicted to decrease the exposure to
dasatinib.rStudy
▶Dasatinibis predicted to increase the exposure tostatins
(simvastatin).oTheoretical
Daunorubicin→see anthracyclines
Decitabine→seeTABLE 15p. 850 (myelosuppression)
Deferasirox→see iron chelators
Deferiprone→seeTABLE 15p. 850 (myelosuppression)
▶Antacids(aluminium hydroxide)are predicted to decrease the
absorption ofdeferiprone. Avoid.oTheoretical
▶Ascorbic acidis predicted to increase the risk of cardiovascular
side-effects when given withdeferiprone.rTheoretical908 Darifenacin—Deferiprone BNFC 2018 – 2019
Interactions|Appendix 1A1