Efavirenz(continued)
▶Efavirenzis predicted to decrease the exposure tocrizotinib.
Avoid.rTheoretical→Also seeTABLE 9p. 849
▶Efavirenzis predicted to decrease the exposure todaclatasvir.
Adjust dose.rStudy
▶Efavirenzis predicted to decrease the exposure todasatinib.
rStudy→Also seeTABLE 9p. 849
▶Efavirenzis predicted to decrease the efficacy ofdesogestrel.
For FSRH guidance, seeContraceptives, interactionsp. 497.
rTheoretical
▶Efavirenzdecreases the exposure todolutegravir. Adjust dose.
rStudy
▶Efavirenzis predicted to moderately decrease the exposure to
elbasvir. Avoid.rStudy
▶Efavirenzis predicted to decrease the exposure toeliglustat.
oTheoretical
▶Efavirenzis predicted to decrease the concentration of
elvitegravir. Avoid.rTheoretical
▶Efavirenzis predicted to decrease the effects ofergotamine.
oTheoretical
▶Efavirenzis predicted to decrease the exposure toerlotinib.
rTheoretical
▶Efavirenzis predicted to decrease the efficacy ofetonogestrel.
For FSRH guidance, seeContraceptives, interactionsp. 497.
rTheoretical
▶Efavirenzis predicted to decrease the exposure toetravirine.
Avoid.rStudy
▶Efavirenzis predicted to decrease the concentration of
everolimus. Avoid or adjust dose.rStudy
▶Efavirenzis predicted to decrease the exposure togefitinib.
Avoid.rTheoretical
▶Efavirenzis predicted to decrease the exposure toglecaprevir.
Avoid.rStudy
▶Efavirenzis predicted to markedly decrease the exposure to
grazoprevir. Avoid.rStudy
▶Efavirenzis predicted to decrease the concentration of
guanfacine. Adjust dose.oTheoretical
▶Efavirenzdecreases the exposure toHIV-protease inhibitors.
Refer to specialist literature.rStudy→Also seeTABLE 9
p. 849
▶Efavirenzis predicted to decrease the effects ofhormone
replacement therapy.oAnecdotal
▶Efavirenzis predicted to decrease the exposure toidelalisib.
Avoid.oTheoretical
▶Efavirenzis predicted to decrease the exposure toimatinib.
oStudy
▶Efavirenzis predicted to decrease the exposure toivacaftor.
rTheoretical
▶Efavirenzis predicted to decrease the exposure tolapatinib.
Avoid.rStudy→Also seeTABLE 9p. 849
▶Efavirenzis predicted to decrease the efficacy of
levonorgestrel. For FSRH guidance, seeContraceptives,
interactionsp. 497.rTheoretical
▶Efavirenzis predicted to decrease the exposure tolurasidone.
Monitor and adjust dose.oTheoretical
▶Efavirenzdecreases the exposure tomacrolides
(clarithromycin).oStudy→Also seeTABLE 9p. 849
▶Efavirenzdecreases the exposure tomaraviroc. Refer to
specialist literature.rTheoretical
▶Efavirenzis predicted to alter the effects ofmidazolam. Avoid.
oTheoretical
▶Efavirenzis predicted to decrease the exposure tonetupitant.
oTheoretical
▶Nevirapinedecreases the concentration ofefavirenz. Avoid.
rStudy
▶Efavirenzis predicted to decrease the exposure tonilotinib.
Avoid.rTheoretical→Also seeTABLE 9p. 849
▶Efavirenzis predicted to decrease the efficacy of
norethisterone. For FSRH guidance, seeContraceptives,
interactionsp. 497.rAnecdotal
▶Efavirenzis predicted to decrease the exposure toolaparib.
Avoid.oTheoretical
▶Efavirenzdecreases the exposure toopioids(methadone).
Monitor and adjust dose.rStudy→Also seeTABLE 9p. 849▶Efavirenzis predicted to decrease the exposure toosimertinib.
oTheoretical→Also seeTABLE 9p. 849
▶Efavirenzis predicted to decrease the exposure toparitaprevir
(with ritonavir and ombitasvir). Avoid.rStudy
▶Efavirenzis predicted to decrease the exposure to
phosphodiesterase type-5 inhibitors.oTheoretical→Also
seeTABLE 9p. 849
▶Efavirenzis predicted to decrease the exposure topibrentasvir.
Avoid.rStudy
▶Pitolisantis predicted to decrease the exposure toefavirenz.
qTheoretical
▶Efavirenzis predicted to decrease the exposure toquetiapine.
oStudy
▶Efavirenzis predicted to decrease the exposure toribociclib.
oStudy→Also seeTABLE 9p. 849
▶Efavirenzslightly decreases the exposure torifabutin. Adjust
dose.rStudy
▶Rifampicinslightly decreases the exposure toefavirenz. Adjust
dose.rStudy
▶Efavirenzis predicted to decrease the exposure torilpivirine.
Avoid.rTheoretical
▶Efavirenzis predicted to decrease the exposure torolapitant.
Avoid.rStudy
▶Efavirenzis predicted to decrease the exposure toruxolitinib.
Monitor and adjust dose.oTheoretical
▶Efavirenzis predicted to decrease the exposure tosimeprevir.
Avoid.rStudy
▶Efavirenzis predicted to decrease the concentration of
sirolimus. Monitor and adjust dose.oTheoretical
▶St John’s Wortis predicted to decrease the concentration of
efavirenz. Avoid.rTheoretical
▶Efavirenzslightly decreases the exposure tostatins
(atorvastatin).nStudy
▶Efavirenzmoderately decreases the exposure tostatins
(simvastatin).oStudy
▶Efavirenzis predicted to decrease the concentration of
tacrolimus. Monitor and adjust dose.oTheoretical
▶Efavirenzis predicted to decrease the exposure totaxanes
(cabazitaxel). Avoid.rStudy
▶Efavirenzis predicted to decrease the concentration of
temsirolimus. Avoid.rTheoretical
▶Efavirenzis predicted to decrease the exposure toticagrelor.
oTheoretical
▶Efavirenzis predicted to decrease the exposure totofacitinib.
oStudy
▶Efavirenzis predicted to decrease the exposure totolvaptan.
oTheoretical
▶Efavirenzdecreases the efficacy ofulipristal. For FSRH
guidance, seeContraceptives, interactionsp. 497.r
Anecdotal
▶Efavirenzis predicted to decrease the exposure tovelpatasvir.
Avoid.oTheoretical
▶Efavirenzis predicted to decrease the exposure tovenetoclax.
Avoid.rStudy
▶Efavirenzis predicted to decrease the concentration of
voxilaprevir. Avoid.rTheoretical
Elbasvir
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toelbasvir. Avoid.rStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)
slightly to moderately increase the exposure toelbasvir.
Avoid.oStudy
▶Bosentanis predicted to moderately decrease the exposure to
elbasvir. Avoid.rStudy
▶Cobicistatslightly to moderately increases the exposure to
elbasvir. Avoid.oStudy
▶Elbasviris predicted to increase the concentration of
dabigatran.oTheoretical
▶Efavirenzis predicted to moderately decrease the exposure to
elbasvir. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure toelbasvir.
Avoid.rStudy
▶Etravirineis predicted to decrease the exposure toelbasvir.
Avoid.qTheoretical914 Efavirenz—Elbasvir BNFC 2018 – 2019
Interactions|Appendix 1A1