▶Crizotinibis predicted to increase the risk of ergotism when
given withergometrine.rTheoretical
▶Ergometrineis predicted to increase the risk of ergotism when
given withdopamine receptor agonists(cabergoline, pergolide).
Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
ergometrine.rTheoretical
▶HIV-protease inhibitorsare predicted to increase the risk of
ergotism when given withergometrine. Avoid.r
Theoretical
▶Idelalisibis predicted to increase the risk of ergotism when
given withergometrine. Avoid.rTheoretical
▶Imatinibis predicted to increase the risk of ergotism when
given withergometrine.rTheoretical
▶Macrolides(clarithromycin)are predicted to increase the risk of
ergotism when given withergometrine. Avoid.r
Theoretical
▶Macrolides(erythromycin)are predicted to increase the risk of
ergotism when given withergometrine.rTheoretical
▶Netupitantis predicted to increase the risk of ergotism when
given withergometrine.rTheoretical
▶Nilotinibis predicted to increase the risk of ergotism when
given withergometrine.rTheoretical
▶Ergometrinepotentially increases the risk of peripheral
vasoconstriction when given withsympathomimetics, inotropic
(dopamine). Avoid.rAnecdotal
▶Ergometrineis predicted to increase the risk of peripheral
vasoconstriction when given withsympathomimetics,
vasoconstrictor(noradrenaline/norepinephrine).rAnecdotal
Ergotamine
▶Almotriptanis predicted to increase the risk of
vasoconstriction when given withergotamine.Ergotamine
should be taken at least 24 hours before or 6 hours after
almotriptan.rTheoretical
▶Antiarrhythmics(dronedarone)are predicted to increase the
risk of ergotism when given withergotamine.rTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the effects of
ergotamine.oTheoretical
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the risk of ergotism when given with
ergotamine.rTheoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the risk of ergotism when given with
ergotamine. Avoid.rTheoretical
▶Antifungals, azoles(miconazole)are predicted to increase the
exposure toergotamine. Avoid.oTheoretical
▶Aprepitantis predicted to increase the risk of ergotism when
given withergotamine.rTheoretical
▶Beta blockers, non-selectiveare predicted to increase the risk
of peripheral vasoconstriction when given withergotamine.
rStudy
▶Beta blockers, selectiveare predicted to increase the risk of
peripheral vasoconstriction when given withergotamine.
rStudy
▶Bosentanis predicted to decrease the effects ofergotamine.
oTheoretical
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the risk of ergotism when given withergotamine.
rTheoretical
▶Ceritinibis predicted to increase the exposure toergotamine.
Avoid.rTheoretical
▶Cobicistatis predicted to increase the risk of ergotism when
given withergotamine. Avoid.rTheoretical
▶Crizotinibis predicted to increase the risk of ergotism when
given withergotamine.rTheoretical
▶Ergotamineis predicted to increase the risk of ergotism when
given withdopamine receptor agonists(bromocriptine,
cabergoline). Avoid.oTheoretical
▶Ergotamineis predicted to increase the risk of ergotism when
given withdopamine receptor agonists(pergolide).o
Theoretical
▶Efavirenzis predicted to decrease the effects ofergotamine.
oTheoretical
▶Eletriptanincreases the risk of vasoconstriction when given
withergotamine. Separate administration by 24 hours.r
Study
▶Enzalutamideis predicted to decrease the effects of
ergotamine.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
ergotamine.rTheoretical
▶HIV-protease inhibitorsare predicted to increase the risk of
ergotism when given withergotamine. Avoid.rTheoretical
▶Idelalisibis predicted to increase the risk of ergotism when
given withergotamine. Avoid.rTheoretical
▶Imatinibis predicted to increase the risk of ergotism when
given withergotamine.rTheoretical
▶Macrolides(clarithromycin)are predicted to increase the risk of
ergotism when given withergotamine. Avoid.rTheoretical
▶Macrolides(erythromycin)are predicted to increase the risk of
ergotism when given withergotamine.rTheoretical
▶Mitotaneis predicted to decrease the effects ofergotamine.
oTheoretical
▶Naratriptanis predicted to increase the risk of
vasoconstriction when given withergotamine. Separate
administration by 24 hours.rTheoretical
▶Netupitantis predicted to increase the risk of ergotism when
given withergotamine.rTheoretical
▶Nevirapineis predicted to decrease the effects ofergotamine.
oTheoretical
▶Nilotinibis predicted to increase the risk of ergotism when
given withergotamine.rTheoretical
▶Palbociclibis predicted to increase the exposure to
ergotamine. Adjust dose.oTheoretical
▶Ribociclib(high-dose) is predicted to increase the exposure to
ergotamine. Avoid.oTheoretical
▶Rifampicinis predicted to decrease the effects ofergotamine.
oTheoretical
▶Rizatriptanis predicted to increase the risk of vasoconstriction
when given withergotamine.Ergotamineshould be taken at
least 24 hours before or 6 hours afterrizatriptan.r
Theoretical
▶St John’sWortis predicted to decrease the effects of
ergotamine.oTheoretical
▶Sumatriptanincreases the risk of vasoconstriction when given
withergotamine.Ergotamineshould be taken at least 24 hours
before or 6 hours aftersumatriptan.rStudy
▶Ticagreloris predicted to increase the exposure toergotamine.
Avoid.rTheoretical
Eribulin→seeTABLE 15p. 850 (myelosuppression),TABLE 12p. 850
(peripheral neuropathy),TABLE 9p. 849 (QT-interval prolongation)
Erlotinib
FOOD AND LIFESTYLEDose adjustment may be necessary if
smoking started or stopped during treatment.
▶Antacidsare predicted to decrease the absorption oferlotinib.
Antacidsshould be taken 4 hours before or 2 hours after
erlotinib.oTheoretical
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
increase the exposure toerlotinib.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toerlotinib. Avoid or adjusterlotinibdose.rStudy
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure toerlotinib.o
Theoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to slightly increase the exposure toerlotinib. Use
with caution and adjust dose.oStudy
▶Aprepitantis predicted to increase the exposure toerlotinib.
oTheoretical
▶Erlotinibis predicted to increase the risk of gastrointestinal
perforation when given withaspirin(high-dose).r
Theoretical
▶Bosentanis predicted to decrease the exposure toerlotinib.
rTheoretical
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure toerlotinib.oTheoretical
▶Ciclosporinis predicted to increase the exposure toerlotinib.
oTheoreticalBNFC 2018 – 2019 Ergometrine—Erlotinib 919
Interactions|Appendix 1A1