▶Antiepileptics(eslicarbazepine, oxcarbazepine)potentially
decrease the exposure toglecaprevir. Avoid.rTheoretical
▶Antifungals, azoles(itraconazole, ketoconazole)potentially
increase the exposure toglecaprevir.oTheoretical
▶Bosentanis predicted to decrease the exposure toglecaprevir.
Avoid.rStudy
▶Ciclosporinincreases the exposure toglecaprevir. Avoid or
monitor.rStudy
▶Cobicistatpotentially increases the exposure toglecaprevir.
oTheoretical
▶Crizotinibpotentially decreases the exposure toglecaprevir.
Avoid.rTheoretical
▶Glecaprevir(with pibrentasvir) increases the exposure to
dabigatran. Avoid.oStudy
▶Glecaprevir(with pibrentasvir) increases the exposure to
digoxin.oStudy
▶Efavirenzis predicted to decrease the exposure toglecaprevir.
Avoid.rStudy
▶HIV-protease inhibitors(atazanavir, darunavir, lopinavir)
(boosted with ritonavir) increase the exposure toglecaprevir.
Avoid.rStudy
▶HIV-protease inhibitors(ritonavir)potentially increase the
exposure toglecaprevir.rTheoretical
▶Lumacaftorpotentially decreases the exposure toglecaprevir.
Avoid.rTheoretical
▶Nevirapineis predicted to decrease the exposure to
glecaprevir. Avoid.rStudy
▶Rifampicinmarkedly affects the exposure toglecaprevir.
Avoid.rStudy
▶St John’s Wortis predicted to decrease the exposure to
glecaprevir. Avoid.rStudy
▶Glecaprevir(with pibrentasvir) increases the exposure to
statins(atorvastatin, simvastatin). Avoid.oStudy
▶Glecaprevir(with pibrentasvir) is predicted to increase the
exposure tostatins(fluvastatin).oTheoretical
▶Glecaprevir(with pibrentasvir) increases the exposure to
statins(pravastatin). Use with caution and adjustpravastatin
dose.oStudy
▶Glecaprevir(with pibrentasvir) increases the exposure to
statins(rosuvastatin). Use with caution and adjustrosuvastatin
dose,p. 133.oStudy
Glibenclamide→see sulfonylureas
Gliclazide→see sulfonylureas
Glimepiride→see sulfonylureas
Glipizide→see sulfonylureas
Glucagon
▶Glucagonincreases the anticoagulant effect ofcoumarins
(warfarin).rStudy
Glucosamine
▶Glucosamineincreases the anticoagulant effect ofcoumarins
(warfarin). Avoid.oAnecdotal
Glucose→seeTABLE 3p. 847 (anticoagulant effects)
Glycerol phenylbutyrate
▶Antiepileptics(valproate)potentially oppose the effects of
glycerol phenylbutyrate.oTheoretical
▶Corticosteroidspotentially oppose the effects ofglycerol
phenylbutyrate.oTheoretical
▶Haloperidolpotentially opposes the effects ofglycerol
phenylbutyrate.oTheoretical
Glyceryl trinitrate→see nitrates
Glycopyrronium→seeTABLE 10p. 849 (antimuscarinics)
Golimumab→see monoclonal antibodies
Granisetron→seeTABLE 13p. 850 (serotonin syndrome),TABLE 9
p. 849 (QT-interval prolongation)
▶Dopamine receptor agonists(apomorphine)are predicted to
increase the risk of severe hypotension when given with
granisetron.rTheoretical
Grapefruit juice
▶Grapefruit juicemoderately decreases the exposure to
aliskiren. Avoid.rStudy
▶Grapefruit juiceincreases the exposure toantiarrhythmics
(amiodarone). Avoid.oStudy
▶Grapefruit juicemoderately increases the exposure to
antiarrhythmics(dronedarone). Avoid.rStudy
▶Grapefruit juiceincreases the exposure toantiarrhythmics
(propafenone). Monitor and adjust dose.oStudy
▶Grapefruit juiceslightly increases the exposure toantiepileptics
(carbamazepine). Monitor and adjust dose.oStudy
▶Grapefruit juiceslightly decreases the exposure to
antihistamines, non-sedating(bilastine).Bilastineshould be
taken 1 hour before or 2 hours aftergrapefruit juice.o
Study
▶Grapefruit juiceincreases the exposure toantihistamines, non-
sedating(rupatadine). Avoid.oStudy
▶Grapefruit juiceincreases the exposure toantimalarials
(artemether).qStudy
▶Grapefruit juiceis predicted to increase the concentration of
antimalarials(piperaquine). Avoid.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
axitinib.oTheoretical
▶Grapefruit juicegreatly decreases the exposure tobeta blockers,
selective(celiprolol).oStudy
▶Grapefruit juiceis predicted to increase the exposure to
bosutinib. Avoid.oTheoretical
▶Grapefruit juiceincreases the exposure tobuspirone. Avoid.
nStudy
▶Grapefruit juiceis predicted to increase the exposure to
cabozantinib.oTheoretical
▶Grapefruit juicevery slightly increases the exposure tocalcium
channel blockers(amlodipine). Avoid.nStudy
▶Grapefruit juiceincreases the exposure tocalcium channel
blockers(felodipine). Avoid.oStudy
▶Grapefruit juiceis predicted to increase the exposure tocalcium
channel blockers(lercanidipine). Avoid.oTheoretical
▶Grapefruit juiceincreases the exposure tocalcium channel
blockers(nicardipine).nStudy
▶Grapefruit juiceincreases the exposure tocalcium channel
blockers(nifedipine, verapamil). Avoid.nStudy
▶Grapefruit juiceis predicted to increase the exposure to
ceritinib. Avoid.rTheoretical
▶Grapefruit juiceincreases the concentration ofciclosporin.
Avoid.rStudy
▶Grapefruit juicemarkedly decreases the exposure to
clopidogrel.rStudy
▶Grapefruit juiceis predicted to increase the exposure to
cobimetinib. Avoid.rTheoretical
▶Grapefruit juicemoderately increases the exposure to oral
corticosteroids(budesonide). Avoid.oStudy
▶Grapefruit juiceis predicted to increase the exposure to
crizotinib. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
darifenacin.oStudy
▶Grapefruit juiceis predicted to increase the exposure to
dasatinib. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
eliglustat. Avoid.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
ergometrine.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
ergotamine.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
erlotinib.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
everolimus. Avoid.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
guanfacine. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
ibrutinib. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
imatinib.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
ivabradine. Avoid.oStudy
▶Grapefruit juiceis predicted to increase the exposure to
ivacaftor. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
lapatinib. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.o
TheoreticalBNFC 2018 – 2019 Glecaprevir—Grapefruit juice 925
Interactions|Appendix 1A1