BNF for Children (BNFC) 2018-2019

Loperamide(continued)

▶Mirabegronis predicted to increase the exposure to

loperamide.nTheoretical

▶Opicaponeis predicted to increase the exposure toloperamide.

Avoid.oStudy

▶Velpatasviris predicted to increase the exposure to

loperamide.rTheoretical

Lopinavir→see HIV-protease inhibitors

Loprazolam→seeTABLE 11p. 849 (CNS depressant effects)

Loratadine→see antihistamines, non-sedating

Lorazepam→seeTABLE 11p. 849 (CNS depressant effects)

▶Rifampicinincreases the clearance oflorazepam.o

Study

Lormetazepam→seeTABLE 11p. 849 (CNS depressant effects)

Losartan→see angiotensin-II receptor antagonists

Low molecular-weight heparins→seeTABLE 16p. 851 (increased

serum potassium),TABLE 3p. 847 (anticoagulant effects)

dalteparin.enoxaparin.tinzaparin..

▶Ranibizumabincreases the risk of bleeding events when given

withlow molecular-weight heparins.rTheoretical

Loxapine→seeTABLE 8p. 848 (hypotension),TABLE 11p. 849 (CNS

depressant effects),TABLE 10p. 849 (antimuscarinics)

▶Combined hormonal contraceptivesare predicted to increase

the exposure toloxapine. Avoid.qTheoretical

▶Loxapineis predicted to decrease the effects ofdopamine

receptor agonists.oTheoretical→Also seeTABLE 8

p. 848→Also seeTABLE 10p. 849

▶Loxapineis predicted to decrease the effects oflevodopa.

rTheoretical→Also seeTABLE 8p. 848

▶Quinolones(ciprofloxacin)are predicted to increase the

exposure toloxapine. Avoid.qTheoretical

▶SSRIs(fluvoxamine)are predicted to increase the exposure to

loxapine. Avoid.qTheoretical

Lumacaftor

▶Lumacaftoris predicted to decrease the exposure to

antiepileptics(carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone). Avoid.rTheoretical

▶Lumacaftoris predicted to decrease the exposure to

antifungals, azoles(fluconazole). Adjust dose.nTheoretical

▶Lumacaftoris predicted to decrease the exposure to

antifungals, azoles(itraconazole, ketoconazole, posaconazole,

voriconazole). Avoid or monitor efficacy.oTheoretical

▶Lumacaftoris predicted to decrease the exposure to

ciclosporin. Avoid.rTheoretical

▶Lumacaftoris predicted to decrease the efficacy ofcombined

hormonal contraceptives. Use additional contraceptive

precautions.rTheoretical

▶Lumacaftoris predicted to decrease the exposure to

corticosteroids(methylprednisolone, prednisone). Adjust dose.

rTheoretical

▶Lumacaftoris predicted to decrease the exposure to

everolimus. Avoid.rTheoretical

▶Lumacaftorpotentially decreases the exposure toglecaprevir.

Avoid.rTheoretical

▶Lumacaftoris predicted to decrease the efficacy of

levonorgestrel. Use additional contraceptive precautions.

rTheoretical

▶Lumacaftoris predicted to decrease the exposure tomacrolides

(clarithromycin, erythromycin).oTheoretical

▶Lumacaftoris predicted to decrease the exposure to

midazolam. Avoid.rTheoretical

▶Lumacaftorpotentially decreases the exposure topibrentasvir.

Avoid.rTheoretical

▶Lumacaftoris predicted to decrease the exposure torifabutin.

Adjust dose.oTheoretical

▶Lumacaftoris predicted to decrease the exposure tosirolimus.

Avoid.rTheoretical

▶Lumacaftoris predicted to decrease the exposure to

tacrolimus. Avoid.rTheoretical

▶Lumacaftoris predicted to decrease the exposure to

temsirolimus. Avoid.rTheoretical

▶Lumacaftoris predicted to decrease the efficacy ofulipristal.

Use additional contraceptive precautions.rTheoretical

Lumefantrine→see antimalarials

Lurasidone→seeTABLE 8p. 848 (hypotension),TABLE 11p. 849 (CNS

depressant effects)

▶Antiarrhythmics(dronedarone)are predicted to increase the

exposure tolurasidone.oStudy

▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone)are predicted to decrease the exposure

tolurasidone. Avoid.oStudy→Also seeTABLE 11p. 849

▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)

are predicted to increase the exposure tolurasidone.o

Study

▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are

predicted to increase the exposure tolurasidone. Avoid.

rStudy

▶Aprepitantis predicted to increase the exposure tolurasidone.

oStudy

▶Bosentanis predicted to decrease the exposure tolurasidone.

Monitor and adjust dose.oTheoretical

▶Calcium channel blockers(diltiazem, verapamil)are predicted to

increase the exposure tolurasidone.oStudy→Also see

TABLE 8p. 848

▶Cobicistatis predicted to increase the exposure tolurasidone.

Avoid.rStudy

▶Crizotinibis predicted to increase the exposure tolurasidone.

oStudy

▶Efavirenzis predicted to decrease the exposure tolurasidone.

Monitor and adjust dose.oTheoretical

▶Enzalutamideis predicted to decrease the exposure to

lurasidone. Avoid.oStudy

▶Grapefruit juiceis predicted to increase the exposure to

lurasidone. Avoid.rTheoretical

▶HIV-protease inhibitorsare predicted to increase the exposure

tolurasidone. Avoid.rStudy

▶Idelalisibis predicted to increase the exposure tolurasidone.

Avoid.rStudy

▶Imatinibis predicted to increase the exposure tolurasidone.

oStudy

▶Lurasidoneis predicted to decrease the effects oflevodopa.

rTheoretical→Also seeTABLE 8p. 848

▶Macrolides(clarithromycin)are predicted to increase the

exposure tolurasidone. Avoid.rStudy

▶Macrolides(erythromycin)are predicted to increase the

exposure tolurasidone.oStudy

▶Mitotaneis predicted to decrease the exposure tolurasidone.

Avoid.oStudy

▶Netupitantis predicted to increase the exposure tolurasidone.

oStudy

▶Nevirapineis predicted to decrease the exposure tolurasidone.

Monitor and adjust dose.oTheoretical

▶Nilotinibis predicted to increase the exposure tolurasidone.

oStudy

▶Rifampicinis predicted to decrease the exposure tolurasidone.

Avoid.oStudy

▶St John’s Wortis predicted to decrease the exposure to

lurasidone. Monitor and adjust dose.oTheoretical

Lymecycline→see tetracyclines

Macitentan

▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,

phenytoin, primidone)are predicted to decrease the exposure

tomacitentan. Avoid.rStudy

▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are

predicted to increase the exposure tomacitentan.o

Study

▶Cobicistatis predicted to increase the exposure tomacitentan.

oStudy

▶Enzalutamideis predicted to decrease the exposure to

macitentan. Avoid.rStudy

▶HIV-protease inhibitorsare predicted to increase the exposure

tomacitentan.oStudy

▶Idelalisibis predicted to increase the exposure tomacitentan.

oStudy

▶Macrolides(clarithromycin)are predicted to increase the

exposure tomacitentan.oStudy

▶Mitotaneis predicted to decrease the exposure tomacitentan.

Avoid.rStudy

946 Loperamide—Macitentan BNFC 2018 – 2019

Interactions

|Appendix 1

A1