BNF for Children (BNFC) 2018-2019

▶Netupitantis predicted to increase the exposure to
antihistamines, non-sedating(rupatadine). Avoid.oStudy
▶Netupitantis predicted to increase the concentration of
antimalarials(piperaquine).rTheoretical
▶Netupitantis predicted to increase the exposure toaxitinib.
oTheoretical
▶Netupitantis predicted to increase the exposure to
bedaquiline. Avoid prolonged use.nTheoretical
▶Bosentanis predicted to decrease the exposure tonetupitant.
oTheoretical
▶Netupitantis predicted to increase the exposure tobosutinib.
Avoid or adjust dose.rTheoretical
▶Netupitantis predicted to increase the exposure tobuspirone.
Use with caution and adjust dose.oStudy
▶Netupitantis predicted to increase the exposure to
cabozantinib.oTheoretical
▶Netupitantis predicted to increase the exposure tocalcium
channel blockers(amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nifedipine, nimodipine). Monitor and
adjust dose.oStudy
▶Netupitantis predicted to increase the exposure toceritinib.
oTheoretical
▶Netupitantincreases the concentration ofciclosporin.r
Study
▶Cobicistatis predicted to increase the exposure tonetupitant.
oStudy
▶Netupitantis predicted to increase the exposure to
cobimetinib.rTheoretical
▶Netupitantis predicted to increase the exposure tocolchicine.
Adjustcolchicinedose with moderate inhibitors of CYP3A4.
rStudy
▶Netupitantis predicted to increase the exposure to
corticosteroids(dexamethasone). Adjust dose.oStudy
▶Netupitantis predicted to increase the exposure to
corticosteroids(methylprednisolone). Monitor and adjust dose.
oStudy
▶Netupitantis predicted to slightly increase the exposure to
darifenacin.oStudy
▶Netupitantis predicted to increase the exposure todasatinib.
rStudy
▶Netupitantincreases the risk of QT-prolongation when given
withdomperidone. Avoid.rStudy
▶Netupitantis predicted to increase the exposure todopamine
receptor agonists(bromocriptine).rTheoretical
▶Netupitantis predicted to increase the concentration of
dopamine receptor agonists(cabergoline).oAnecdotal
▶Netupitantis predicted to moderately increase the exposure to
dutasteride.nStudy
▶Efavirenzis predicted to decrease the exposure tonetupitant.
oTheoretical
▶Netupitantis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Enzalutamideis predicted to decrease the exposure to
netupitant. Avoid.rStudy
▶Netupitantis predicted to increase the risk of ergotism when
given withergometrine.rTheoretical
▶Netupitantis predicted to increase the risk of ergotism when
given withergotamine.rTheoretical
▶Netupitantis predicted to increase the exposure toerlotinib.
oTheoretical
▶Netupitantis predicted to increase the concentration of
everolimus. Avoid or adjust dose.oStudy
▶Netupitantis predicted to increase the exposure to
fesoterodine. Adjustfesoterodinedose with moderate
inhibitors of CYP3A4 in hepatic and renal impairment.n
Study
▶Netupitantis predicted to increase the exposure togefitinib.
oTheoretical
▶Netupitantis predicted to increase the concentration of
guanfacine. Adjustguanfacinedose,p. 231.oTheoretical
▶HIV-protease inhibitorsare predicted to increase the exposure
tonetupitant.oStudy
▶Netupitantis predicted to increase the exposure toibrutinib.
Adjustibrutinibdose with moderate inhibitors of CYP3A4.
rStudy

▶Idelalisibis predicted to increase the exposure tonetupitant.

oStudy

▶Netupitantis predicted to increase the exposure toimatinib.

oTheoretical

▶Netupitantis predicted to increase the exposure toivabradine.

Adjustivabradinedose.rTheoretical

▶Netupitantis predicted to increase the exposure toivacaftor.

Adjustivacaftordose with moderate inhibitors of CYP3A4,

p. 186.rStudy

▶Netupitantis predicted to increase the exposure tolapatinib.

oStudy

▶Netupitantis predicted to increase the exposure tolomitapide.

Avoid.oTheoretical

▶Netupitantis predicted to increase the exposure tolurasidone.

oStudy

▶Macrolides(clarithromycin)are predicted to increase the

exposure tonetupitant.oStudy

▶Netupitantis predicted to increase the exposure tomidazolam.

Monitor side effects and adjust dose.rStudy

▶Netupitantis predicted to increase the exposure to

midostaurin.oTheoretical

▶Mitotaneis predicted to decrease the exposure tonetupitant.

Avoid.rStudy

▶Netupitantis predicted to increase the exposure tonaloxegol.

Adjustnaloxegoldose and monitor side effects.oStudy

▶Nevirapineis predicted to decrease the exposure tonetupitant.

oTheoretical

▶Netupitantis predicted to increase the exposure tonilotinib.

oTheoretical

▶Netupitantis predicted to increase the exposure toolaparib.

Avoid moderate inhibitors of CYP3A4 or adjustolaparibdose.

oTheoretical

▶Netupitantis predicted to increase the exposure toopioids

(alfentanil, buprenorphine, fentanyl, oxycodone). Monitor and

adjust dose.oStudy

▶Netupitantis predicted to increase the exposure toopioids

(methadone, sufentanil).oTheoretical

▶Netupitantis predicted to increase the exposure tooxybutynin.

nTheoretical

▶Netupitantis predicted to increase the exposure topazopanib.

oTheoretical

▶Netupitantis predicted to increase the exposure to

phosphodiesterase type-5 inhibitors(avanafil). Adjustavanafil

dose.oTheoretical

▶Netupitantis predicted to increase the exposure to

phosphodiesterase type-5 inhibitors(sildenafil). Monitor or

adjustsildenafildose with moderate inhibitors of CYP3A4,

p. 120.oStudy

▶Netupitantis predicted to increase the exposure to

phosphodiesterase type-5 inhibitors(tadalafil).rTheoretical

▶Netupitantis predicted to increase the exposure to

phosphodiesterase type-5 inhibitors(vardenafil). Adjust dose.

rTheoretical

▶Netupitantis predicted to increase the exposure topimozide.

Avoid.rTheoretical

▶Netupitantis predicted to increase the exposure toquetiapine.

Avoid.oStudy

▶Netupitantis predicted to increase the exposure toranolazine.

rStudy

▶Netupitantis predicted to increase the exposure toribociclib.

oStudy

▶Rifampicinis predicted to decrease the exposure tonetupitant.

Avoid.rStudy

▶Netupitantis predicted to increase the exposure toruxolitinib.

oTheoretical

▶Netupitantis predicted to increase the exposure tosaxagliptin.

nStudy

▶Netupitantis predicted to increase the exposure tosimeprevir.

Avoid.rStudy

▶Netupitantincreases the concentration ofsirolimus. Monitor

and adjust dose.oStudy

▶Netupitantis predicted to increase the exposure toSSRIs

(dapoxetine). Adjustdapoxetinedose with moderate inhibitors

of CYP3A4.oTheoretical

BNFC 2018 – 2019 Netupitant—Netupitant 961

Interactions

|Appendix 1

A1