USMLE Step 2 CK Lecture Notes 2019: Obstetrics/Gynecology (Kaplan Test Prep)

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day 22–23 of the cycle. The β-hCG becomes positive when the zygote implants
into the endometrium, usually 7–8 days after ovulation. Therefore, the serum β-
hCG becomes positive before the missed period.

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