Medical Microbiology

450 8 VirusesasHumanPathogen

StructureandGenomicOrganizationofHIV

LTR

vpr

gag vif

p55

env

nef

gp 1 60

pol

rev

tat

Structural proteins

Genomic organization

Envelope

Capsid

p18 p24 p1 5

RNA

p66/51/1 0 p3 1

LTR

vpu

gp 1 20 gp 4 1

Fig.8. 14

Gene Geneproduct Function

Structuralgenes:

gag p55 p55 Nucleocapsid,precursorofp18,p24,p1 5

p1 8 Matrixprotein

p2 4 Capsidprotein

pol Polymeraseregion

p66/51/1 0 Reversetranscriptase/RNase/protease

p3 1 Integrase

env gp1 60 Glycoprotein,precursorofgp120,gp4 1

gp1 20 Surfaceprotein(bindstoCD4moleculeofhost

cell)

gp4 1 Transmembraneprotein

Regulatorygenes,seetext.

8

Kayser, Medical Microbiology © 2005 Thieme