Medical Microbiology

Table 1 2. 10 SkinandSubcutaneousConnectiveTissue(localorsystemic infectionswithmainlycutaneousmanifestation)

Infection Mostimportantpathogens Laboratorydiagnosis

a)Viruses Smallpox Variolavirus Parapoxviruses(orfvirus, milker’snodulesvirus)

Electronmicroscopyofvesicle/ pustulecontent;isolation; serology;(usereference laboratory)

Herpes Herpessimplexvirus Electronmicroscopyofvesicle content;cellculture

Varicella (chickenpox)

Varicellazostervirus Serology(IgG,IgM);electron microscopyofvesiclecontent; directIF,cellculture

Measles (morbilli,rubeola)

Measlesvirus(Morbillivirus) Isolationfrompharyngeallavage andurineifrequired;serology

Germanmeasles (rubella)

Rubellavirus(Rubivirus) Serology

Hemorrhagic fever

Bunyaviruses(e.g.,hantavirus) Arenaviruses Flaviviruses(e.g.,Dengue viruses) Marburgvirus Ebolavirus

Serology;cellcultureandPCR frombloodorliverasrequired; animaltestasrequired;labora- torydiagnosisonlypossiblein referencelaboratories

Molluscum contagiosum

Molluscumcontagiosumvirus Microscopyofskinlesions;mol- luscumbodies

Warts Papillomas

Papillomavirus GenomictestwithDNAprobeor electronmicroscopy

Erythema infectiosum

ParvovirusB1 9 Serology

Exanthema subitum

Humanherpesvirus 6 (HHV6) Serology

650 12 EtiologicalandLaboratoryDiagnosticSummariesinTabularForm

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