Biology Questions and Answers
XhY. Concerning the phenotypes, factor
VIII is produced in every individual withat least one nonaffected X chromosome. (^)
So the women XX and X Xh and the
men XY are normal. Oand men XhY have the disease.nly women XhXh
- Why is it rare to find
hemophilic women?
There are more hemophilic mehemophilic women because womenn than
need to have two X chromaffected to develop the disease wosomeshile in (^)
men the disease manifests when the
single X chromosome is affected.
- Is it possible for any son
of a couple formed by a
hemophilic man (XhY) and a
nonhemophilic noncarrier
(XX) woman to be hemophilic?
If mothers are not affected by the
disease annot have an Xh alleled noncarrie) it is impossiblers of the gene (do
for their sons to be hemophilic since the
X chromosome from the mother. Hemophilic sons arof males always comese
only possible when the mother is
hemophilic (homozyghemophilic gene, a very rarous for thee situation) (^)
or carriers of an affected X chromosome
(XXh).
- What is the clinical
manifestation of the disease
known as daltonism?
The X-linked daltonism is a disease inwhich the red color as graffected individeen or confounds theseual sees the (^)
two colours.
- What is the type of genetic
inheritance of daltonism? Is
daltonism more frequent in
men or in women? What is the
physiological explanation for
the daltonism?
Daltonism is a recessive X-linkeinheritance (gene situated in thed
nonhomologous portion of the X
chromosome).
Daltonism is more frequent in men since
in them only the single X cneeds to be affected for the disease tohromosome (^)
manifest. In women it is necessary for
both X chthe disease to comromosomes to e out.be affected for
The disease the gene that coappears ddifies a ue to a defect inretinal pigment (^)
sensitive to red.
- Are sex-linked diseases
associated only to genes of
the X chromosome?
There are many X-linked diseases, like
hemophilia A, hadrenoleukodystropemophilia B anhy, but known Y-d
linked diseases are few and very rare.
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