calcium, chromium,magnesium,selenium,zinc,L-
carnitine, acetyl L-carnitine, coenzyme Q10, gluta-
mine, pycnogenol or grape seed extract, gamma lino-
lenic acid, and turmeric. Among his recommended
topical creams and lotions arevitamin Cester, alpha
lipoic acid, dimethylaminoethanol (DMAE), polye-
nylphosphatidylcholine(PPC), and tocotrienol. The
company also sells dozens of products that target
specific areas of the body (such as the face, eyes, and
lips), specific problems (dull skin, acne, dry skin, and
spider veins), along with products for men’s skin care,
weight loss, and sun protection. His weight-loss prod-
ucts (and their prices as of April 2007) include a 5.3-
ounce (oz.) pouch of polysaccharide peptide blend
($65), 10.1-oz. of L-glutamine powder ($60), 270 soft-
gel omega-3 fatty acids supplements ($97), and a 30-
day supply of 90 maitake caplets ($60).
Function
The primary function of the Perricone diet is to
slow the aging process by counteracting the body’s
inflammatory process, resulting in healthier and
younger looking skin and over-all appearance. Its sec-
ondary function is as a weight loss program that
stresses a diet high in antioxidants and low in carbo-
hydrates. Weight loss for overweight or obese people
can lead to a lower risk for a number of diseases,
including some types ofcancer, heart disease, diabe-
tes, high blood pressure, and high cholesterol. Diet
specifics vary slightly among the six major books writ-
ten by Perricone as of 2007. Since the diet has asoy
component, it can be adapted to a vegetarian diet but
probably not vegan. Omega-3 fatty acids can be
obtained fromflaxseedoil rather than fish.
Benefits
Benefits include living longer and looking
younger, according to Perricone. Specifically, Perri-
cone says his diet plan will reduce wrinkles, slow or
reverse the visible aging process, clear acne, and elim-
inate bags and dark circles around the eyes. Perricone
says this is because his diet plan reduces inflammation
in the body, which is the root of most of the physical
appearance issues associated with aging. The Perri-
cone diet and others like it can be beneficial in reduc-
ing the risks of many medical problems, such as heart
disease and diabetes, since it emphasizes eating fish,
vegetables, and fruit.
Precautions
The Perricone diet recommends regulating blood
sugar levels by eating foods that have a low glycemic
index. The American Dietary Association, the Amer-
ican Diabetes Association, the American Heart Asso-
ciation, and the United States Department of
Agriculture do not endorse low GI diets and these
organizations do not support extreme intakes of fish.
Such extreme intakes make the diet unbalanced. Since
the diet advocates the use of numerous dietary supple-
ments, persons considering the Perricone diet should
check with their doctor or pharmacist to see if any of
the supplements interact with any prescription medi-
cation they are taking. Persons who are on a blood
thinner, such as Coumadin (warfarin) should consult
their doctor before going on the diet. Women who are
pregnant or lactating should not go on the diet without
consulting their physician or obstetrician. People with
existing medical conditions, including heart disease
and diabetes, should discuss the diet with their physi-
cian before starting it.
Risks
In the UK, the FSA have set upper limits for oily
fish consumption that are no more than two portions
per week for girls and women of childbearing age and
no more than four portions per week for boys, men,
and older women due to the risk of contamination.
Research and general acceptance
Although his books have been best-sellers in the
United States and elsewhere, there is not general
acceptance of most of his philosophy and claims by
the medical community. There is also very little scien-
tific research to substantiate most of his claims regard-
ing the anti-aging aspects of his diet. There is research
that shows a diet low in carbohydrates can promote
weight loss but most of the studies followed partici-
pants for a year or less.
The consumer watchdog Website Quackwatch
(http://www.quackwatch.org) takes a skeptical view
of many of the claims made by Perricone. ‘‘Dr. Perri-
cone would be more credible if he could show us a
study demonstrating that people who followed his
prescription lived longer, had younger skin demon-
strated by objective measures, or felt better than
those on a placebo program—or that they were better
in any measurable way,’’ physicians Harriet Hall and
Stephen Barrett wrote in a Quackwatch article dated
August 12, 2004. ‘‘Instead, he provides only testimo-
nials, exaggerated claims, partial truths, and incorrect
statements.’’ For example, they say the Perricone
books fail to mention that a diet high in salmon may
pose health risks due to mercury contamination in the
Perricone diet