Microsoft Word - blank.doc

706 Unit 30 C NEL

9.Identify the row that best describes the type of mutation

and its consequence to the structure of the protein.

Row Mutation Consequence

A. insertion causes a shift to the reading

frame and results in an

entirely different amino acid

sequence

B. deletion causes a shift to the reading

frame and results in an

entirely different amino acid

sequence

C. substitution causes a different amino

acid at one location

D. inversion causes different amino acids

for the sequence inverted as

reading frame is reversed

10. Select the statement that best describes the codons given
    in the description of thalassemia.
    A. These are mRNA codons as they contain the base
    uracil.
    B. These are mRNA codons as they contain the base
    thyamine.
    C. These are DNA codons as they contain the base
    uracil.
    D. These are DNA codons as they contain the base
    thymine.

Use the following information to answer questions 9 and 10.

Thalassemia is a serious human genetic disorder that causes

severe anemia. People with thalassemia die before sexual

maturity. There are over 90 different mutations that can lead to

thalassemia. One of the mutations changes the codon TAC to

TA A.

Use the following information to answer questions 11 and 12.

1. Initiation commences when the RNA polymerase binds to
   the promoter region of the gene to be transcribed.


2. The ribosome continues to move along the mRNA, reading
   the code in triplets known as codons.


3. When the ribosome moves over, the tRNA containing the
   growing peptide is shifted over to the P site. A third amino
   acid, specified by the third codon, is brought into the A site
   by the next tRNA. A peptide bond is formed between the
   second and third amino acid.


4. A complementary RNA strand is synthesized in the
   direction of 5
   to 3
   , using one strand of DNA as a
   template. This step is known as elongation. The
   complement of adenine in RNA is uracil.


5. New amino acids are added to the chain in the process of
   elongation, which continues until a stop codon is read in
   the A site. The stop codons are UAG, UGA, and UAA. At
   this point, the ribosome stalls.


6. Once the termination sequence is reached by the RNA
   polymerase, the process ceases. The mRNA is separated
   from the DNA and the RNA polymerase falls off the DNA
   molecule.


7. When the start codon is in the P site, a tRNA delivers the
   amino acid methionine. The tRNA recognizes the codon
   because of the complementary anticodon.


8. Identify the statements that describe the process of
   transcription. (Record all three digits of your answer in the
   order in which they would occur in the cell.)


9. Identify the statements that describe the process of
   translation. (Record all four digits of your answer in the
   order in which they would occur in the cell.)

8.Correctly match the cell number in Figure 2with the

condition. (Record all four digits of your answer.)

________ ________ ________ ________

Turner’s trisonomic will not trisonomic

syndrome female survive male

XX XY

XX

normal female

nondisjunction normal

meiosis

normal male

XY

XXX XO OY XXY

12 3 4

Figure 2

NR

NR

NR