180
SECTION III
Central & Peripheral Neurophysiology
- A 50-year-old woman undergoes a neurological exam that indi-
cates loss of pain and temperature sensitivity, vibratory sense,
and proprioception in both legs. These symptoms could be
explained by
A) a tumor on the medial lemniscal pathway in the sacral spinal
cord.
B) a peripheral neuropathy.
C) a large tumor in the sacral dorsal horn.
D) a large tumor affecting the posterior paracentral gyri.
E) a large tumor in the ventral posterolateral and posterome-
dial thalamic nuclei.
CHAPTER RESOURCES
Baron R, Maier C: Phantom limb pain: Are cutaneous nociceptors
and spinothalamic neurons involved in the signaling and
maintenance of spontaneous and touch-evoked pain? A case
report. Pain 1995;60:223.
Blumenfeld H:
Neuroanatomy Through Clinical Cases.
Sinauer
Associates, 2002.
Haines DE (editor):
Fundamental Neuroscience for Basic and Clinical
Applications,
3rd ed. Elsevier, 2006.
Herman J: Phantom limb: From medical knowledge to folk wisdom
and back. Ann Int Med 1998;128:76.
Hopkins K: Show me where it hurts: Tracing the pathways of pain. J
NIH Res 1997;9:37.
Kandel ER, Schwartz JH, Jessell TM (editors):
Principles of Neural
Science,
4th ed. McGraw-Hill, 2000.
Melzack R: The tragedy of needless pain. Sci Am 1991;262:27.
Penfield W, Rasmussen T:
The Cerebral Cortex of Man: A Clinical
Study of Localization of Function.
Macmillan, 1950.
Willis WD: The somatosensory system, with emphasis on structures
important for pain. Brain Res Rev 2007;55:297.