Study 1 : 8D+$1EFG#B+(H/$,+(A+%,'(.<(!%B+(C+<+$'+$
-! 21.&)q$!5.(.0)J!<-(0-#!1)$!(%&/!;)(-#+!+#9#&$.;#!0-&&#(.&/!)&+!
-&+#/%-&+!9%IE<)I%&!,!$-<1!)$!01#!L<(.W!%)+$N!%9!01#!()0#!
3)*.&/!:0)0#$!>#.%+!2@A35763B4C!8)&+!01#!LO#**)<%t)!
3)*.%$N!%9!D$?',"$'E;#?FGH'0%5K!2@A35763B4C!8I!
-! :#;#&!I5#$!.&!01#!1.$0%J!%9!21.&)!01#!>1)$#!L'&+#/%-&+!
M#)0!3)((N!1)$!K##&!-$#+!.&!01#!<%&0#B0!%9!5.(.0)J!+#9#&$#l!
-! O1#!5%$0!#<#&0!)>>(.<)I%&!%9!01#!0#5!FF!L5J$0#*.%-$!
-&+#/%-&+!M#)0!3)((N!FF!4)$!$#<#0(J!)>>(.#+!0%!01#!#W%*0!0%!
K-.(+!$#<-#!K)$.&/!9%!01#!$0)0#/.<!&-<(#)!%<=#0!9%<#!.&!01#!
ST]7$C!E$0!)5K./-%-$(J!#9##&<#+!.&!>.&0!.&!01#!5.+FT7$?!)&+!
%^<.)((J!#&$1.&#+!)$!)!L&)I%&)(!>%#<0N!.&;%(;.&/!Q?777!5.(#$!
%9!0-&&#($!%&!SS!e#<@!A77T@!