0071643192.pdf

TOXICOLOGY

TABLE 6.25. Antidotes for Specific Toxicologic Agents (Continued)

ANTIDOTE INGESTION/EXPOSURE INDICATIONS FORTREATMENT

N-acetylcysteine (NAC) Acetaminophen Acute single ingestion: Use Rumack-Matthew nomogram

Unknown time or repeated supra-therapeutic ingestion:

Elevated AST/ALT

APAP level > 10 μcg/mL

Naloxone Opioid toxicity Respiratory depression

Octreotide Sulfonlyurea overdose Recurrent hypoglycemia

Physostigmine Anticholinergic toxidrome Delirium

(rarely indicated) Seizures

Dysrhythmias

Pralidoxime (2-PAM) Organophosphates Symptomatic poisonings

Vitamin K Warfarin Increased INR (escalating dosing)

Bleeding

COMPLICATIONS

■ Cardiac ischemia
■ Aortic dissection
■ Ruptured abdominal aorta
■ Ischemic bowel
■ Perforated viscus
■ Rhabdomyolysis