OBSTETRICS AND GYNECOLOGY
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■ A modern copper IUD does not increase the risk of ectopic compared to
no contraception, but if a women becomes pregnant with an IUD, then
the risk of ectopic is high (approximately 3%).
SYMPTOMS
■ Abdominal pain
■ Vaginal bleeding—common, but not always present
■ Dizziness or syncope (less common)
EXAM
■ Vital signs may be normal or hypotension may be present due to hemor-
rhagic shock.
■ A relative bradycardia may be present secondary to vagal stimulation.
■ The pelvic/abdominal exam may be normalor can have localized tender-
ness including CMT.
■ Adnexal tenderness or adnexal mass may not always be present on exam.
DIFFERENTIAL
The differential for a woman of childbearing age with abdominal/pelvic pain
or abnormal vaginal bleeding includes:
■ Ectopic pregnancy ■ Mittelschmerz
■ Appendicitis/cholecystitis ■ Intrauterine pregnancy
■ Ovarian cyst/torsion ■ Threatened abortion
■ PID ■ Inevitable abortion
■ Endometriosis ■ Molar pregnancy
■ UTI/renal colic ■ Heterotopic pregnancy
■ Inflammatory bowel disease (IBD) ■ Corpus luteum cyst
DIAGNOSIS
■ Ectopic pregnancy should be considered in all women of childbearing age
who present with abdominal or pelvic pain, especially those with unex-
plained signs/symptoms of hypovolemia.
■ Positive pregnancy test is an almost universal finding in the diagnosis of ec-
topic (very dilute urine or switched urine samples may lead to a false nega-
tive!).
■ Ultrasound is the test of choice in evaluating pregnant patients with com-
plaints consistent with ectopic pregnancy (see Figure 12.2).
■ The finding of a yolk sac, a double decidual sac, or fetal cardiac activity
inside the uterus is considered diagnostic for IUP. A gestational sac alone
is not diagnosticfor IUP because it may be confused with a pseudosac,
which is often present in patients with extrauterine pregnancy.
■ Aβ-hCG facilitates ultrasound interpretation. The “discriminatory zone”
(theβ-hCG level above which an IUP should be visualized by ultrasound)
for transvaginal ultrasound is 1000–1500 IU/mL; for transabdominal ultra-
sound it is about 4000–6500 IU/mL.
■ Above the discriminatory zone, it should be possible to identify an IUP.
Failure to do so mandates OB/GYN consultation for presumed ectopic.
■ Aβ-hCG level below the discriminatory zone and an ultrasound that fails
to show an intrauterine pregnancy is consistent with either an early IUP or
an ectopic pregnancy.
■ Heterotopic pregnancy must be considered in unstable patients with find-
ings diagnostic for IUP. Look at the adnexa and look for signs of simultane-
ous ectopic pregnancy or free fluid.
All females of childbearing
age with abdominal pain
should be presumed pregnant
until proven otherwise.
Classic triad for ectopic
pregnancy:
Abdominal pain
Vaginal bleeding
Positive pregnancy test
Mittelschmerz: Midcycle
(half-way between periods)
pain associated with
ovulation, usually sharp,
usually on one side