0071643192.pdf

PSYCHOBEHAVIORAL DISORDERS

TABLE 16.10. Serotonergic Potential of Various Drugs

EXTREMEPOTENCY MODERATEPOTENCY LOWPOTENCY NONE

Amitriptyline Amphetamine Amantadine Acetaminophen

Citalopram Buspirone Bromocriptine Granisetron

Clomipramine Cocaine Bupropion Metoclopramide

Dexfenfluramine Desipramine Carbamazepine Morphine

Dextromethorphan Doxepin Cisapride NSAIDs

Fenfluramine Levodopa Codeine Ondansetron

Fluoxetine LSD Pentazocine Salicylates

Fluvoxamine Mescaline Pergolide

Imipramine Mirtazapine Reserpine

Isocarboxazid Nefazodone

L-Tryptophan Nortriptyline

5-Hydroxytryptophan St. John’s wort‡

(5-HTP)‡

Lithium Sumatriptan

MDMA Trazodone

Meperidine

Moclobemide*

Pargyline†

Paroxetine

Phenelzine

Selegiline

Sertraline

Tramadol

Tranylcypromine

Venlafaxine

(Reproduced, with permission, from Tintinalli JE, Kelen, GD, Stapczynski SJ. Emergency Medicine:
A Comprehensive Study Guide, 6th ed.New York: McGraw-Hill, 2004:1038.)
*Not available in the United States.
†No longer manufactured in the United States.
‡Over-the-counter herbal product.
Note:The serotonergic potential of the drugs listed was determined by both objective and sub-
jective criteria and can be influenced by different doses and formulations.
Abbreviations:LSD = lysergic acid diethylamide; MDMA = 3,4-methylenedioxymethamphetamine;
NSAIDs = nonsteroidal anti-inflammatory drugs.