(answer e)into bundles by actin-binding proteins such as the bundling
protein α-actinin and the gel-forming protein (fimbrin). The following
table lists the location of the major types of collagen.
184 Anatomy, Histology, and Cell Biology
∗I General C.T., bone, Most abundant type of collagen, 67-nm
and fibrocartilage periodicity, tensile strength
∗II Hyaline and elastic Thinner fibrils than type I, tensile strength,
cartilage electrostatic interactions between type II
collagen and proteoglycan aggregates form
the molecular basis for the rigidity of
hyaline cartilage
∗III Spleen, bone marrow, Reticular framework, stains with silver
and lymph nodes
∗IV Basement membrane Filtration, support, meshwork scaffolding,
interacts with heparan sulfate proteoglycan
to produce a polyanionic charge distribution
that facilitates selective filtration; synthesized
by epithelia; it retains propeptides that are
used to form a meshwork; also interacts
with fibronectin
V Placental basement Linkage function in basement membrane (?)
membrane, muscle
basal lamina
VII Basement membrane Anchoring fibers
of skin and amnion
VIII Endothelium Angiogenesis, bridging ECM components
IX–XII Cartilage Fibril-associated collagens with interrupted
triple helices (FACIT) regulate orientation
and function of fibrillar collagens∗Most common collagen types and most testable
MAJOR COLLAGEN TYPES
Type Location Function and Other Information93.The answer is a.(Junqueira, pp 107, 111, 367. Alberts, p 1100.)The
patient in the vignette is suffering from Ehlers-Danlos Syndrome (EDS)
type IV (also known as EDS of the vascular type). In this disorder there is
improperly formed type III collagen, which is responsible for the elasticity