121.If a laboratory were designing an effective therapy to prevent the
spread of metastatic osteosarcoma, which of the following approaches
would most likely be successful?
a. Enhancement of fibronectin-integrin interactions
b. Enhancement of laminin-integrin interactions
c. Upregulation of selectins on endothelial cells
d. Upregulation of TIMPs at the primary tumor site
e. Downregulation of angiostatin or endostatin at the primary tumor site
122.A 28-year-old woman visits your family medicine clinic complaining of
loss of sense of smell, nosebleeds, problems with swallowing, and hoarseness.
She admits to “casual, social use” of cocaine on a regular basis since her sopho-
more year of college when her “boyfriend turned her on to cocaine at a party.”
You complete examination of her nose with a speculum and otoscope and
determine that she has rhinitis (inflammation). There is also perforation and
collapse of the nasal cartilage resulting in a “saddle nose” deformity. You also
note erosions in the enamel of her front teeth. The breakdown of the nasal car-
tilage releases collagen fibers primarily of which type?
a. Type I
b. Type II
c. Type III
d. Type IV
e. Type VII
204 Anatomy, Histology, and Cell Biology