Urinary System 387256.A 15-year-old boy presents with hematuria, hearing loss, lens dislo-
cation, and cataracts. Genetic analysis shows a mutation of the COL4A5
gene. A renal biopsy is performed. In which area labeled A–E on the
accompanying electron micrograph would you expect to see the primary
site of damage?
a. Area A
b. Area B
c. Area C
d. Area D
e. Area E
(Electron micrograph courtesy of Dr. Dale R. Abrahamson.)