(continued)
(8) (a) How are Craig plots used in Hansch analysis? (b) Use Figure 4.6 to predict
the structures of the analogues of compond A in question (7) that would
be likely to have a high antiseptic activity.(9) (i) Describe how the Topliss decision tree is used in drug design.
(ii) What are the major limitations to its use?QUESTIONS 93