(continued)
(5) Explain the meaning of the term ‘suicide inhibitor’.
(6) Explain how the transition state of a reaction can be used to design an
enzyme inhibitor.(7) Distinguish between competitive and noncompetitive antagonists.
(8) Explain the meaning of the term antimetabolite. Outline, in general terms,
the mode of action of antimetabolite drugs.(9) Draw the general structure of nitrogen mustards. How do these drugs inhibit
the transcription of DNA?(10) What are antisense drugs? How do they inhibit nucleic acids?
(11) Outline, using suitable examples, the general modes of action of antiviral
drugs.158 SELECTED EXAMPLES OF DRUG ACTION AT SOME COMMON TARGET AREAS