FIRST INTERNATIONAL CAENORHABDITIS ELEGANS EXPERIMENT: PHYSIOLOGICAL AND
Influence of Weightlessness on the Activation of NF-ĸβ Proteins (Kappa)
Research Area: Cellular Biology
Expedition(s): 8 and 9
Principal Investigator(s): ● Maikel Peppelenbosch, Erasmus Medical Center, Rotterdam
Netherlands
RESEARCH OBJECTIVES
The main scientific objectives of the Influence of
Weightlessness on the Activation of NF-ĸβ Proteins
(Kappa) experiment are to establish whether in
weightlessness phagocytic cells of the myeloid
lineage either retain or lose the capacity to react to
lipopolysaccharide from gram-negative bacteria with
the activation of nuclear factor kappa B (NF- ĸβ).
RESULTS
Data analysis from this investigation is ongoing.
This investigation is complete; however additional
results are pending publication.
Immunostaining of NF- ĸβ in unstimulated blood
cells (top) or LPS-stimulated cells (bottom). M.
Peppelenbosch image.