V-antigen isolated from cells of the recombinant strain Escherichia coli HB101/pVHB62 exposed
to microgravity was identical in terms of molecular mass, spectral properties, and
immunochemical properties to V341 antigen obtained from control cultures kept on Earth.
PUBLICATION(S)
Abramov VM, Khlebnikov VS, Vasiliev AM, et al. A study of the interaction of Yersinia Pestis
virulence factors with 1L-1R/TLR recognition system. Totowa, NJ: National Institute of Allergy
and Infections Diseases, NIH; 2008.
Abramov VM, Khlebnikov VS, Vasiliev AM, et al. Attachment of LcrV from Yersinia Pestis at dual
binding sites to human TLR-2 and human IFN-gamma receptor. Journal of Proteome Research.
June 2007;6(6):2222-2231. doi: 10.1021/pr070036r.
Mueller CA, Broz P, Mueller SA, et al. The V-Antigen of Yersinia forms a distinct structure at the
tip of injectisome needles. Science. October 28, 2005;310:674-676.
Derewenda U, Mateja A, Devedjiev Y, et al. The structure of Yersinia Pestis V-Antigen, an
essential virulence factor and mediator of immunity against plague. Structure. 2004;12:301-
- doi: 10.1016/j.str.2004.01.010.
This investigation is complete; however additional results are pending publication.