(Mode of Action of Drugs)
PharmacodynamicsPharmacodynamicsPharmacodynamicsPharmacodynamicsPharmacodynamicsPharmacodynamicsPharmacodynamicsPharmacodynamicsPharmacodynamicsPharmacodynamics
Chapter
1.4
Chapter
2.5 Psychotropic Agents
Psychotropic
Agents
Psychopharmacological agents may be clas-
sified into three broad groups used in vari-
ous states of psychic disorders.
- Antipsychotic drugs or major tranquil-
lizers used in all types of psychosis
mainly schizophrenia. - Antianxiety drugs or minor tranquil-
lizers used in anxiety.
3. Antidepressants for minor and major
depressive disorders and mood
stabilisers (antimanic drugs) for mania.
ANTIPSYCHOTIC DRUGS
(MAJOR TRANQUILLIZERS)They are classified as in table 2.5.1.Table 2.5.1: Classification of antipsychotic drugs.
I. Phenothiazines
Chlorpromazine (MEGATIL) 100-800 mg/day
Triflupromazine (SIQUIL) 50-200 mg/day
Trifluoperazine (NEOCALM) 5-15 mg BD
II. Butyrophenones
Haloperidol (HEXIDOL) 5-10 mg/day
Droperidol (DROPEROL) 10 mg IM, 5-15 mg/day IV
Trifluperidol (TRIPERIDOL) 0.5-8 mg/day
III.Other newer compounds
Loxapine (LOXAPAC) 60-100 mg BD-QID
Clozapine (SIZOPIN) 25-50 mg/day
Pimozide (PIMODAC) 3-4 mg/day
Zuclopenthixol (CLOPIXOL) 20-40 mg IM repeated 2-4 week interval
Molindone 20-200 mg/day
Sulpiride 0.4-2 g/day
Sertindole 4-24 mg/day