110 Section 2/ Drugs Acting on CNSAfter oral administration, it is rapidly
absorbed and widely distributed into all
tissues. It readily crosses blood brain
barrier and is not bound to plasma proteins.
It is excreted unchanged in urine. It is
mainly used as adjunctive therapy in
treatment of partial seizures with or
without secondary generalization in adults.
Adverse effects include sedation,
dizziness, diplopia, ataxia and fatigue.
VIGABATRIN
It is an inhibitor of GABA transaminase
which degrades GABA. It suppresses
maximal electroshock and kindled seizures
and is used in partial seizure with or without
generalization.
It is well absorbed after oral administra-
tion and excreted unchanged in urine.
Adverse effects include drowsiness,
dizziness, agitation and amnesia.