Pharmacology for Dentistry

Sympatholytics (Antiadrenergic Agents) 153

CELIPROLOL

It is beta 1 selective blocker with a
modest capacity to activate beta 2 receptors
also. It is used in treating hypertension and
angina pectoris.

NEBIVOLOL

Nebivolol is a new selective β 1 -
adrenergic blocking agent that possesses a
unique pharmacodynamic profile, by which
it differs from traditional β 1 -blockers.

Nebivolol is quite safe and is well
tolerated. The most common adverse effects
are dizziness, headache and fatigue. Owing
to its combined dual mechanism of action,
nebivolol leads to a unique haemodynamic
and therapeutic profile by which it may be
advantageous in essential hypertension,
ischemic heart disease and congestive heart
failure.

βββββ 2 SELECTIVE BLOCKERS

BUTOXAMINE

It is selective beta 2 blocker, but does not

have any efficacious role in clinical practice.

THERAPEUTIC USES OF BETA

BLOCKERS

1. Hypertension.


2. Ischemic heart disease, angina pectoris.


3. Cardiac arrhythmias.


4. Hypertrophic cardiomyopathy.


5. Congestive heart failure.


6. Myocardial infarction.


7. Pheochromocytoma.


8. Hyperthyroidism.


9. Neurologic diseases: Migraine, anxiety,
   essential tremor.


10. Glaucoma.