Sources and Nature of Drug Dosage Form 5- Oil of clove is mainly useful in
relieving pain in toothache.
iv. Resins are produced by oxidation and
polymerization of volatile oils. The
different types of resins are: - Oleoresins: Male fern extract used
for tapeworm infestation. - Gum resins: Asafoetida, used as
carminative and antispasmodic. - Oleo gum resin: Myrrh, it has a local
stimulant and antiseptic properties
and generally used in mouthwash. - Balsams: Benzoin, used internally
as expectorant and externally as
astringent. - Balsam Tolu, used as stimulating
expectorant.
v. Gums are the secretory products of
plants. On hydrolysis they yield simple
sugar like polysaccharides. They are
pharmacologically inert substances
and mainly employed as suspending
and emulsifying agent in various
pharmaceutical products.
The widely used preparations are gum
acacia and tragacanth.
vi. Tannins are nonnitrogenous constitu-
ents of plant. Chemically they are phe-
nolic derivatives and are characterized
by their astringent action. Tannins are
generally employed in the treatment of
diarrhoea and burns. The important
plants which contains tannins are:
Amla, Behera, Hirda (in combination
form ‘Triphala’), Black catechu and
Ashoka bark.
ANIMAL SOURCES
The different animal products after
purification in a suitable dosage form for the
treatment of disease are listed in table 1.1.1.
FROM HUMAN BEING
There are certain products which are
obtained from human being e.g.- Immunoglobulins: From blood.
- Placental extract: From placenta.
- Chorionic gonadotropin: From urine
of pregnant women. - Growth hormone: From pituitary
gland.
FROM MICROORGANISMS
The different classes of drugs obtained/
isolated from microbes are:- Penicillin: Penicillium chrysogenum
and notatum (Fungus). - Streptomycin: Streptomyces griseus
(Actino-mycetes). - Erythromycin: Streptomyces erythreus
(Actinomycetes). - Chloramphenicol: Streptomyces
venezuelae (Actinomycetes). - Tetracyclines: Streptomyces aureofaciens
and rimosus (Actinomycetes). - Polymyxin B: Bacillus polymyxa.
- Bacitracin: Bacillus subtilis.
- Nystatin: Streptomyces nouresi.
- Griseofulvin: Penicillium griseofulvum.
Apart from various other antibiotics
obtained from microorganisms, there are
other products that are also produced by
microorganisms. They are: - Streptokinase, an enzyme from gram
positive cocci (Streptococcus pyogenes). - Vitamin B 12 (cyanocobalamin):
Streptomyces griseus.