354 Section 9/ Chemotherapy
It is used in the treatment of chloroquine
resistant malaria and cerebral malaria.
ARTEMETHER
It is derivative of artemisinin. These
agents produce a more rapid clearance
of parasites than quinine, chloroquine
and mefloquine in treatment of severe
cerebral and falciparum malaria. It is a
effective drug against all strains resistant
to other antimalarial agents.
It is a schizonticidal drug and leads to
destruction of asexual erythrocytic forms
of P. falciparum and P. vivax. There is
inhibition of protein synthesis during
growth of trophozoites.