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analytical techniques such as mass spectrometry (see Chapter 9) and invariably

requiring the interrogation of protein and genome sequence data on the Web (bioin-

formatics, Section 5.8). It is then necessary to determine which other proteins interact

with the protein being studied. Proteomics is thus moving us away from studying

proteins in isolation and encouraging us to consider the proteins in the cell as part

Fig. 8.9An interaction map of the yeast proteome, assembled from published interactions (see text for details).

(Courtesy of Benno Schwikowski, Peter Uetz and Stanley Fields. Reprinted with the permission of Nature

Publishing Group.) (See also colour plate.)

350 Protein structure, purification, characterisation and function analysis