Medicinal Chemistry

APPENDIX 3.1: BASIC REACTIONS FOR DRUG

MOLECULE SYNTHESIS

A. Building Blocks for the Framework Structure:

C-C, C=C, C≡C, and C-H Bond Formation

C-C Bond Formation

166 MEDICINAL CHEMISTRY

1. Acetoacetic ester synthesis


2. Aldol reaction


3. Alkylation of ketone enolate anion


4. Claisen condensation


5. Claisen rearrangement