features: an affinity for 5-HT 2 serotonin receptors as well as for D2 receptors, and relative
anatomical selectivity for limbic structures rather than for basal ganglia structures
within the brain. Clozapine also exhibits high affinity for dopamine receptors of the D4
subtypes in addition to H 1 histamine and muscarinic acetylcholine receptors. Clozapine
may also lead to bone marrow failure (agranulocytosis), mandating the need for close
blood monitoring for people on this agent.
NEUROTRANSMITTERS AND THEIR RECEPTORS 245