Medicinal Chemistry

(Jacob Rumans) #1

ibutilide (7.24). Class IV compounds include traditional Ca^2 +channel blockers such as
verapamil (7.25) and diltiazem (7.26).


7.4.4 Targeting the Sodium Channel Protein: Anticonvulsants

Seizures are the brain’s equivalent to cardiac arrhythmias. Like arrhythmias, seizures
are not a disease but rather a symptom of some underlying pathology. The human brain


ENDOGENOUS CELLULAR STRUCTURES 421
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