synthesized by treating p-aminophenyl butyric acid with ethylene oxide, followed by
thionyl chloride. Although the nitrogen mustards did not fulfil expectations regarding
selectivity, they are nevertheless useful oral drugs when employed in conjunction with
tumor surgery. Ovarian and breast carcinomas, lymphadenoma, and multiple myeloma are
the malignancies most successfully treated with these drugs, especially in combination
with mitosis inhibitors.
ENDOGENOUS CELLULAR STRUCTURES 447