Medicinal Chemistry

(Jacob Rumans) #1

8.1.2.3 Functional Catalytic Proteins: Enzymes


More than 3000 different enzymes have been identified and characterized. For purposes
of drug design, these enzymes may be grouped into six main classes, according to the
reaction that they catalyze; in turn, within each group, there are a variety of different
enzymes:



  1. Hydrolases
    Amidases
    Caspases
    Esterases
    Glycosidases
    Lipases
    Nucleases
    Exonucleases
    Endonucleases
    Peptidases
    Proteases

  2. Isomerases
    Cis/trans-isomerases
    Epimerases
    Mutases
    Racemases
    Rotamases

  3. Ligases
    Carboxylases
    DNA ligase
    RNA ligase
    Synthetases

  4. Lyases
    Aldolases
    Decarboxylases

  5. Oxidoreductases
    Catalases
    Dehydrogenases
    Oxidases
    Oxygenases
    Peroxidases
    Reductases

  6. Transferases
    Acetyltransferases
    Kinases
    Polymerases
    Transaldolases
    Transaminases
    Transketolases
    Transmethylases


468 MEDICINAL CHEMISTRY

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