aromatic electrophilic substitution, 128
aromatic nucleophilic substitution, 128
arrhythmia, heart, 379, 420–421
arsenic poisoning, 594
arsenical antibiotics, 535
arsphenamine, 535
arteries, brain, 202
ASA, 14, 16, 157, 525
ascending cholangitis, 316
ascorbic acid, 508
aspartate, 283
aspirin, 14, 16, 157, 525
astemizole, 266
asthma, 232, 233, 265, 424, 450
astrocytes, 195
AT III, 529
AT 1 antagonists, 379, 380
ataxia, 512
atheromas, 317
atherosclerosis, 317, 379
cerebral artery, 379
coronary artery, 379
postmenopausal, 324
renal artery, 379
peripheral artery, 379
atherosclerotic plaques, 317
atorvastatin, 318, 430
atovaquone, 586
ATPase, 492–494
atrial natriuretic peptides, 376
atrioventricular node, 419
atrophic vaginitis, 324
atropine, 14, 18, 109, 491, 530, 531
auranofin, 533
autocoids, 520
autonomic nervous system, 202–204
autoproteolysis, 501
avitaminosis A, 509
AVP, 348
axon, 194
azapropazone, 525
azathioprine, 18, 393
azidothymidine, 554
aziridines, 152, 449
azithromycin, 577
azole antifungals, 583
AZT, 554
aztreonam, 569
baclofen, 272, 273
bacteria, drug targets, 561
bacteriocidal agent, 560
bacteriostatic agent, 560
Baeyer-Villiger oxidation, 178
Banting, Charles, 110, 364
barbiturates, 102, 277, 278
basal ganglia, 200
basophil, 390
BAY K 8644, 429
Bayliss, 310
Beckmann rearrangement, 179
bemidone, 357
benign prostatic hypertrophy, 212, 231
benperidol, 245
benzestrol, 322
benzilic acid rearrangement, 177
benzocaine, 417
benzodiazepines, 102, 111, 123, 274, 275
benzomorphan, 357
benztropine, 241
D-2-benzylsuccinic acid, 373
bepridil, 427
Bergström, 472
beriberi, 504
Best, 364
β-blockers, 234–236, 379, 380
bethanechol, 210
bezafibrate, 320
bezoar stone, 109
bicalutamide, 330
bicuculline, 273
biguanides, 367
binding interactions, drug receptor, 78
bioaccumulation, 594
bioactive conformation, 51
bioactive zone, 106
biocrystallization, 517
bioinformatics, 61–63, 127
bioisostere, 8, 21–23, 139
biophore, 8, 19–20, 106
biotin, 506–507
biperiden, 249
bipolar affective disorder, 236
bismuth, 109, 533
bismuth subsalicylate, 269, 533
bisphosphonates, 18, 536–537
bleomycin, 453, 456, 558
Bloch, 474
blood pH, 13
blood platelet aggregation, 523
blood pressure, 378
blood sugar, 476
blood–brain barrier, 16, 28, 433, 153–154
BNP, 376, 377
Born Oppenheimer approximation, 47
bradycardia, 381, 420, 427
Bragg equation, 57
brain anatomy, 193–198
brain natriuretic peptide, 377
brain peptides, 289, 338–346INDEX 631