Medicinal Chemistry

dimaprit, 264
dimenhydrinate, 266
dimercaprol, 595
dimercaptopropane, 595
dipeptide, 338
diphenhydramine, 14, 266
diplopia, 512
dipole–dipole interactions, 71
diprenorphine, 359
disaccharide, 475
disopyramide, 421
distomer, 38
diuretics, 379, 380, 496
Dixon plot, 83
dizocilopine, 285
DNA, 469
DNA polymerase inhibitor, 553
DNA viruses, 549
DNQX, 286
dobutamine, 439
docking simulations, 55
dofetilide, 421
donepezil, 217, 489, 513
doomsday signal, 501
dopamine, 18, 238
dopamine receptors, 239–245
dose–response curves, 75
double bonds, in drugs, 136
double reciprocal plot, 83
down-regulation, receptor, 76
doxazosin, 231
doxepin, 237
doxorubicin, 447, 456
doxycycline, 573
droperidol, 358
drug delivery, 158, 159
drug molecule, 6, 10, 11
drug stability, 155
drug-like molecule, 6, 10, 11
drug-receptor interactions, 69
druggable target, 11, 378, 409
definition, 69
dura mater, 201
dynorphin, 352
dysmenorrhoea, 350

E 1 , 321
E 2 , 321
E 3 , 321
Easson-Stedman hypothesis, 37
echothiophate, 490
eclampsia, 294
edrophonium, 488
efavirenz, 555
efficacy, 76

Ehrlich, Paul, 67, 110, 562

eicosanoids, 472–473, 519

elastins, 467

electrical process control, 310

electroanalgesia, 351

electrochemical process control, 310

electron-transport chain, 440

electronic descriptors, 43, 143

electronic properties, drugs, 40–44

eliprodil, 286

enalapril, 374, 375, 379

enalaprilat, 374

enalkiren, 373

enantiomers, 37–39

encephalitis, 201, 593

encephalopathy, 490

endocrine disruptors, 596

endocrine system, 310

endocrinology, 310

endometrial carcinoma, 324, 325, 326

endoplasmic reticulum, 408

β-endorphin, 352

endorphins, 351

endothelium derived relaxing factor, 292

energy minimization, 49

enkephalin, 339, 351

enkephalin opiate receptors, 353

enoxacin, 580

enoxaparin, 529

entacapone, 249

enterovirus, 549

enzyme inhibition, mechanisms of, 484

enzymes, 467, 468–469

as drugs and targets, 483–513

eosinophil, 390

ependymal cells, 195

ephedrine, 116

epidural anesthesia, 419

epilepsy, 108, 109, 279, 280, 283,

421–423, 430–432, 495

catamenial, 328

epileptogenesis, 431

epinephrine, 14

epirubicin, 445, 447

epistaxis, 419

epoxide metabolism, 152

eprosartan, 376

Epstein-Barr virus, 549

equilenin, 322

equilin, 322

erectile dysfunction, 293

ergocristine, 349

ergocryptine, 243

ergonovine, 349

ergosterol, 510, 582

INDEX 635