Medicinal Chemistry

Helicobacter pylori, 268
Hell-Volhard-Zellinski reaction, 172
helminths, 585
hemoglobin, 479
heparin, 16, 512, 528
heparins, low-molecular weight (LMW), 529
hepatitis, 396, 549
herbicide poisoning, 594
heroin, 355
herpes virus, 549
heterocodeine, 355
heterocycles, 477–480
as drugs and targets, 529–532
heteropolysaccharide, 475
heteroreceptor, 76
hexachlorophene, 571
hexestrol, 322
hexobarbital, 278
high blood pressure, 234–235, 379
high throughput screening, 124, 125
high-density lipoproteins, 318
Hill plot, 83
hippocampus, 201
histamine, 260–264, 498
histamine receptors, 261, 262
histology, 406
histrelin, 342
hMG, 346
Hoffman elimination, 169, 175
homatropine, 213
homeostasis, 7, 310, 386
HOMO orbital, 43
homo-pyroGlu-His-Pro-NH 2 , 342
homodimerization, 501
homologation, 135
homology modeling, 55
homopolysaccharide, 475
hookworm, 585
hormonal therapy, cancer, 458
hormones
definition, 310
drug design and, 381–382
peptide, 338–382
steroid, 312–337
and their receptors, 341
hsp70, 313
hsp90, 313
human chorionic gonadotropin, 346
human genome project, 125
human menopausal gonadotropin, 346
humoral immunity, 391
Huntington’s disease, 281
hydantoins, 122, 123
hydralazine, 18
hydrocephalus, 202

hydrochlorothiazide, 380

hydrogen bonding, 72

hydrolases, 468

hydrophobic interactions, 73

hydroxyapatite, 536

14-hydroxymorphone, 358

hypercholesterolemias, 318

hyperglycemia, 364

hyperlipoproteinemias, 318

hypertension, 234–235

peptide drug design for, 378–381

hyperthyroidism, 361, 362

hypoadrenalism, iatrogenic, 336

hypocalcemia, 364

hypoglycemia, 364

hypoglycemic agents, 367–369

hypokalemia, 336

hypothalamic neurohormonal peptides, 340–346

hypothalamic–pituitary axis, 338

hypothalamus, 199, 310, 311, 338, 340

hypothyroidism, 361, 362

ibuprofen, 18, 131, 473, 525

ICE, 502

ICE II, 502

ICE III, 502

ICE-B, 503

ICE-C, 503

ICE-LAP3, 502

ICE-LAP6, 503

Ich-1, 502

Ich-2, 502

Ich-3, 503

ICSH, 346

idarubicin, 445, 447

IDDM, 369

idoxuridine, 552

ifenprodil, 287

ifosfamide, 448

ileus, 212

imidazole metabolism, 152

imipramine, 14, 16, 237

immune system, 310

immunoglobulins, 389

immunomodulating drugs, 398–401

immunomodulators, 310

immunosuppressive drugs, 392–394

in silico experiments, 55, 131

indinavir, 556

indole metabolism, 153

indomethacin, 525

induced-fit theory, receptor, 81

infection, 336

infertility drugs, 343

inflammation, 336

638 INDEX