Medicinal Chemistry

Lineweaver-Burke, plot, 83
lipid peroxidation, 411
lipids, 471–474
as drugs and targets, 519
Lipinski’s rule, 10
lipoproteins, 318
5-lipoxygenase inhibitors, 526
lisinopril, 374, 375
lisuride, 248
lithium, 238, 534
lithium carbonate, 534
lithium citrate, 534
lobes, brain, 201
Locock, Charles, 118
lomefloxacin, 581
lomustine, 448–450
lorazepam, 275
losartan, 376
lovastatin, 318
low density lipoproteins, 318
LSD, 256, 257
LT B 4 , 522
LTC/D 4 , 522
LUMO orbital, 43
lung disease, 232
luteinizing hormone, 315, 316, 324, 342, 346
luteinizing hormone-releasing factor, 342–343
lutropin, 315, 316, 324, 342, 346
LVP, 348
lyases, 468
lymphocytes, 389
lymphokines, 392
lypressin, 350
lysine-vasopressin, 348
8-L-lysine vasopressin, 350

MACH, 502
MacKinnon, R, 415
macrolide antibiotics, 576
macromolecular perturbation theory, 81
macromolecules, endogenous, 481–483
macronutrient elements, 481
macrophage, 390
mad cow disease, 514
major groove, DNA, 441, 443–446
malaria, 429, 546, 586, 587
malathion, 158, 490
malignant hyperthermia, 532
maltose, 476
mammary carcinoma, estrogen dependent, 325
manic-depressive illness, 236
MANMETS system, 188–190
mannitol, 528
MAO, 220, 253, 486, 497–499
MAOIs, 498–499

MAPKs, 500

Markovnikov regiochemistry, 173, 174

mast cells, 261

maternal–placental barrier, 16

Mch2, 502

Mch3, 502

Mch4, 503

Mch5, 502

Mch6, 503

mebendazole, 589

mecamylamine, 214

mechlorethamine, 447

meclofenamate, 525

median effective dose, 77

median inhibitory concentration, 77

median toxic dose, 77

medicinal chemistry, definition, 9

medroxyprogesterone acetate, 328

medulla oblongata, 198

mefenamic acid, 525

meglitinides, 367

melanolibrin, 340

melanotropin, 346

MELAS, 440

melathion, 484

melatonin, 250

meloxicam, 525

melphalan, 446, 447

meninges, 201

meningitis, 201, 592

menopause, 324

menses, 321, 326

menstrual cycle, 321

menstrual disorders, 324

meperidine, 138, 357

mepivacaine, 421, 422

6-mercaptopurine, 139, 471

mercurial diuretics, 535

mercury, 109

mercury poisoning, 594

MERRF, 440

mersalyl, 535

mescaline, 257, 258

mesencephalon, 198

messenger RNA, 471

messenger targets, drug design, 98, 99

mestranol, 322, 327

Met-enkephalin, 351

metabolism, drug, 146

metabophore, 8, 19, 106

metabotropic receptors, 432

metagonist, 357

metal hydride reductions, 173

metallo-enzymes, 535

metallotherapy, 109

640 INDEX