Dollinger index

522 ENTREPRENEURSHIP CASE

Region

United States

Europe

Canada

Asia-Pacific

Total

No. of

Listed

Firms

330

98

82

131

641

No. of

Private

Firms

1,114

1,717

390

554

3,775

Total no.

of Biotech

Firms

1,444

1,815

472

685

4,416

Revenue

($ million)

42,740

7,729

2,091

2,052

54,612

R&D Costs

($ million)

15,701

4,151

782

253

20,887

Income/(Loss)

($ million)

(4,317)

(484)

(408)

(94)

(5,303)

Employment

(Number)

137,00 0

25,64 0

7,37 0

13,41 0

183,82 0

SOURCE: Ernst &Young’s “Beyond Borders: Global Biotechnology Report 2005,” http://www.epraire.com/news/vnews, referenced

July 29, 2005.

EXHIBIT 2 GlobalBiotech Firms: Number, Revenue, Income, and Employment By Region, 200 4

Rank

1 2 3 4 5 6 7 8 9

10

11

12

13

14

15

16

17

18

19

20

Company

Amgen

Genentech

Biogen Idec

Genzyme

Applied Biosystems

Priority Healthcare

Chiron

Accredo Health

Gilead Sciences

Medimmune

Biovail

Millenium Pharmaceuticals

Imclone Systems

Biocon

Nektar Therapeutics

Caliper Life Sciences

Celera Genomics

Diversa Corp

Exelixis

Incyte

Country

USA

USA

USA

USA

USA

USA

USA

USA

USA

USA

Canada

USA

USA

India

USA

USA

USA

USA

USA

USA

2004 Sales

(US $million)

10,600

4,620

2,200

2,200

1,740

1,740

1,700

1,500

1,300

1,120

886

448

389

165

114

80

60

58

53

14

EXHIBIT 1 Top 20 Global Biotech Firms

SOURCE: Received from editor of Biospectrum Magazine.