Route and Dosage^432 Depression:● DESVENLAFAXINE● Depression:● ● ● ● ● ● DULOXETINE(e.g., flDecreased effects of zineDecreased effects of Increased effects of duloxetine with CYP1A2 inhibitors (e.g., flsively metabolized by CYP2D6 (e.g., azines, propafenone, tricyclic antidepressants, thiorida-Increased risk of toxicity or adverse effects from drugs exten-Decreased effects of venlafaxine with Increased risk of liver injury with concomitant use of Increased effects of and duloxteineIncreased effects of doses.) 60 mg/day (given either once a day or as 30 mg 2 times a day) (In clinical studies, doses of 50 to 400 mg/day were shown to be effective, although no additional benefidemonstrated at doses greater than 50 mg/day and adverse events and discontinuations were more frequent at higher uvoxamine, quinolone antibiotics) and CYP2D6 inhibitors^ ●) when used concomitantly with duloxetine^ uoxetine, quinidine, paroxetine)PSYCHOTROPIC MEDICATIONS (Cymbalta) PO: PO: (Pristiq) 40 mg/day (given as 20 mg twice a day) to 50 mg once daily, with or without food. indinavirdesipramine warfarinmidazolam and with SNRIs with desvenlafaxinemetoprololwith desvenlafaxinecyproheptadinefl ecainide, phenothi- with venlafaxinealcohol t was
2506_Ch26_417-446.indd 1432 2506 Ch 26 417 - 446 .indDepression, GAD, and Social Anxiety Disorder:Depression:GAD:Fibromyalgia:VENLAFAXINEDiabetic Peripheral Neuropathic Pain:d desirable to start at 30 mg once daily for 1 week to allow the patient to adjust to the medication before increasing to 60 mg Extended-release caps:once daily. in a single dose. May increase dose in increments of up to75 mg/day at intervals of at least 4 days to a maximum of 225 mg/day. without regard to meals. given once daily without regard to meals. day in 2 or 3 divided doses, taken with food. May increase in increments up to 75 mg/day at intervals of at least 4 days. Maximum dosage: 225 mg/day. 1 increase to 60 mg once daily, if needed. 432 PO: 60 mg once daily. For some patients, it may be^ PO(Effexor)^ PO: : Immediate-release tabs: 30 mg once daily for 1 week and then Initial dosage: 75 mg/day, administered Initial dosage: 75 mg/^ PO: 60 mg/day^ PO: 1 10/1/10 9:39:23 AM 0 / 1 / 10 9 : 39 : 23 AM
