● ● ● ● ● ● ● ● ● ● Adverse Reactions and Side Effects● ● ● ● Interactions● ● ● ●^434 SomnolenceOrthostatic hypotensionConstipationuse of trazodone and PriapismHeadacheIncreased risk of suicidality in children and adolescents (black box warning)Drowsiness; dizzinessRisk of hepatic failure (Nervousness; insomniaDecreased effects of trazodone with Increases or decreases in prothrombin time with concurrent Dry mouthIncreased effects of Fatig uedigoxin, done and Risk of serotonin syndrome with concomitant use of trazo-NauseaSymptoms of serotonin syndrome and those resembling Increased effects of trazodone with antifungals,^ ●^ PSYCHOTROPIC MEDICATIONSand SSRIs phenytoinandor protease inhibitorsSNRIswarfarinCNS depressants, carbamazepine, nefazodone with trazodone) (black box warning) carbamazepinephenothiazines, azole
2 2506_Ch26_417-446.indd 1434 506 Ch 26 417 - 446 .ind● Route and DosageDepression:● ● ● ● NEFAZODONEd neuroleptic malignant syndrome may occur with concomitant atorvastatin, lovastatin Increased effects of nefazodoneRisk of serotonin syndrome with concomitant use of nefazo-cisapride, cyclosporine, digoxin, done and Increased effects of both drugs with concomitant use of Risk of rhabdomyolysis with concomitant use of nefazodone use of and buspironeDecreased effects of nefazodone with 1 at least 1 week. Maximum dose: 600 mg/day.2 divided doses. Dose may be increased in increments of 100 to 200 mg/day (on a 2 times a day schedule) at intervals of 434 HMG-CoA reductase inhibitorsMAOIs sibutramine and nefazodone^ PO: and SARIs.Adults: orbenzodiazepines) sumatriptanInitial dosage: 200 mg/day, in and carbamazepineSt. John’s Wort (e.g., , carbamazepinesimvastatin, with , 10/1/10 9:39:24 AM 10 / 1 / 10 9 : 39 : 24 AM
